Hematopoietic stem cells (HSCs) are localized in anatomically and functionally distinctive bone marrow (BM) niches that regulate their regenerative functions in hematopoiesis and immunity; yet the ...

In human blood samples collected for stem cell transplantation, CD34+ cells with a lung signature enriched the mobilized pool of hematopoietic stem cells. These results identify the lung as a pool for uniquely programmed blood stem and progenitor cells with the potential to support hematopoiesis in humans.

Hematopoietic stem cell transplantation (HSCT) is a promising approach in regenerative medicine and serves as a standard treatment for different malignant and non-malignant conditions. Despite its widespread applications, HSCT is associated with various complications that compromise patients’ lives and pose considerable risks of morbidity and mortality. Understanding the molecular physiology ...

Singh, Fernandez-Perez, et al. use hematopoietic stem cell barcoding to study clones with and without activation of cancer driver mutations, identifying that pre-existing stem cell states can dictate resulting (pre-)cancerous phenotypes and showing that inflammation-sensitive stem cells can be a powerful source of malignant evolution.

Haematopoietic stem cells (HSC) and macrophages hold promise for cell-based therapy. Induced pluripotent stem cells (iPSC) offer an alternative to human embryonic stem cells (hESC) for generating haematopoietic cells in vitro, sidestepping ethical concerns. However, precise comparisons of the developmental process and productivity between iPSC and hESC during haematopoietic differentiation are ...