2022年2月25日 · In this minireview, we introduce the basic structure and function of HMGB1 and focus on the regulatory mechanism of HMGB1 secretion and release. Understanding these topics may help us develop...

2023年6月15日 · Fifty years since the initial discovery of HMGB1 in 1973 as a structural protein of chromatin, HMGB1 is now known to regulate diverse biological processes depending on its subcellular or...

2024年12月25日 · HMGB1 (High Mobility Group Box 1) is a Protein Coding gene. Diseases associated with HMGB1 include Brachyphalangy, Polydactyly, And Tibial Aplasia/Hypoplasia and Adams-Oliver Syndrome 1. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Diseases of Immune System.

High mobility group box 1 (HMGB1) is a nonhistone nuclear protein that has multiple functions according to its subcellular location. In the nucleus, HMGB1 is a DNA chaperone that maintains the structure and function of chromosomes. In the cytoplasm, ...

HMGB1 is 215 amino acids long and consists of two DNA binding boxes (A box and B box) as well as a C-terminal tail that is highly enriched in anionic residues. Reflecting this structure, HMGB1 can bind to DNA and histones, with these interactions resulting from …

2005年4月1日 · HMGB1 is a 'leaderless' cytokine, requiring specialized means to gain access to the immunological synapse or to be secreted. By contrast, after DNA damage as a result of apoptotic cell death,...

HMGB1, formally known as high-mobility group protein 1 (HMG-1) or amphoterin, was first discovered in 1973 as a chromosomal non-histone protein and named for its high electrophoretic mobility in polyacrylamide gels (Klune, Dhupar, Cardinal, Billiar, & Tsung, 2008).

In this minireview, we introduce the basic structure and function of HMGB1 and focus on the regulatory mechanism of HMGB1 secretion and release. Understanding these topics may help us develop new HMGB1-targeted drugs for various conditions, especially …

HMGB1 is crucial for DNA-containing ICs to induce anti-dsDNA Ab production; HMGB1 acts through the TLR2-mediated and MyD88-dependent miR-155/Ets-1 pathway. HMGB1 distribution is linked to p53 activity and senescence-associated inflammation; High expression of HMGB1 is associated with T-cell lymphoma.

2023年9月26日 · HMGB1 plays a crucial role in tumor growth and response to therapy and promotes both cell death and survival. HMGB1 involves different pathways associated with cancer development and progression. HMGB1 inhibition can enhance response to immune checkpoint blockade in cancer.