HEP-2细胞（Human Epithelioma-2）最初被认为来源于一名30岁女性的喉部鳞状细胞癌，于1952年首次建立。 然而，后续研究表明，HEp-2细胞的实际来源并非最初所认为的喉癌，而是由于HeLa细胞的污染所致。

Antinuclear antibody (ANA) testing is used in the diagnostic evaluation of various autoimmune diseases, including connective tissue diseases such as systemic lupus erythematosus (SLE), Sjögren syndrome, and systemic sclerosis (SSc). 1 Initial testing for autoimmune connective tissue diseases (also referred to as systemic autoimmune rheumatic dis...

HEp-2 （Human Epithelioma-2）是一种被指属于 学术丑闻 的 细胞系，因为最初它被认为是一种 人类 喉部 鳞状细胞癌 细胞系，但是通过分析后发现起源细胞已经被 海拉细胞 所污染，应为一种与 人类乳突病毒 相关的内子宫腺癌（papillomavirus-related endocervical adenocarcinoma ...

HEp-2细胞系含有HeLa标记染色体，最初认为这个细胞源自喉部表皮样癌，但随后通过同功酶分析、HeLa标记染色体和DNA指纹分析发现，起源细胞已被HeLa污染。 角蛋白免疫过氧化物酶染色阳性。 该细胞株可能存在被HELA污染的可能。 HEp-2的STR分型结果与HELA一致（部分同源性）。 通过PCR证实该细胞系对人乳头瘤病毒DNA序列呈阳性。 细胞在本库通过支原体检测阴性（可供检测报告）。 细胞在本库通过STR检测无误（可供检测报告）。 RPMI 1640培养基 …

The HEp-2 cell line contains HeLa marker chromosomes and were derived via HeLa contamination. This line was originally thought to be derived from an epidermoid carcinoma of the larynx but was subsequently found – based on isoenzyme analysis, HeLa marker chromosomes, and DNA fingerprinting – to have been established via HeLa cell contamination.

HEp-2 （Human Epithelioma-2）是一種被指屬於 學術醜聞 的 細胞系，因為最初它被認為是一種 人類 喉部 鱗狀細胞癌 細胞系，但是通過分析後發現起源細胞已經被 海拉細胞 所污染，應為一種與 人類乳突病毒 相關的內子宮腺癌（papillomavirus-related endocervical adenocarcinoma ...

Hep-2/Hep2 cells are invaluable for researchers engaged in the analysis of autoantibodies, and they are currently one of the most common substrates for antinuclear antibody detection by immunofluorescence [6, 7]. The Hep-2 cell line was first specifically described …

The indirect immunofluorescence assay (IIFA) on HEp-2 cells is widely used for detection of antinuclear antibodies (ANA). The dichotomous outcome, negative or positive, is integrated in diagnostic and classification criteria for several systemic ...

2018年4月29日 · HEp-2 cell line offers the possibility for detection of more than hundred different autoantibodies to nuclear and cytoplasmic autoantigens. The effects of ANA detection with HEp-2 line was the basis of American College of Rheumatology recommend to use of IIF method as the gold standard for ANA detection (screening) [5, 6].

2023年3月21日 · The HEp-2 cell line contains HeLa marker chromosomes and were derived via HeLa contamination. This line was originally thought to be derived from an epidermoid carcinoma of the larynx but was subsequently found – based on isoenzyme analysis, HeLa marker chromosomes, and DNA fingerprinting – to have been established via HeLa cell contamination.