Histone deacetylase 4, also known as HDAC4, is a protein that in humans is encoded by the HDAC4 gene. [5][6] Histones play a critical role in transcriptional regulation, cell cycle …

2024年12月25日 · HDAC4 (Histone Deacetylase 4) is a Protein Coding gene. Diseases associated with HDAC4 include Neurodevelopmental Disorder With Central Hypotonia And …

Among class II HDACs, HDAC4 is implicated in controlling gene expression important for diverse cellular functions. Basic and clinical experimental evidence have well established that HDAC4 …

The HDAC4 gene provides instructions for making an enzyme called histone deacetylase 4. This enzyme is part of a group of related enzymes, called histone deacetylases, that modify …

HDACs are divided into three distinct classes: I, II, and III, on the basis of size and sequence homology, as well as formation of distinct complexes. Among class II HDACs, HDAC4 is …

2021年9月15日 · HDAC4 down-regulation or miR-206 up-regulation contributed to reduced cell apoptosis and the levels of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and …

HDAC4 is a target gene of miR-140 and is involved in miR-140-mediated suppression of osteosarcoma cells. HDAC4 increases endogenous SIRT1 expression by enhancing its …