HCT 116 is an adherent cell line isolated from the colon of a patient with colon cancer. It has a mutation in codon 13 of the ras-proto-oncogene. This cell line is near-diploid and has a relatively stable genetic profile, making it a valuable in vitro model. This line can be utilized in cancer research and gastrointestinal (GI) research.

Understanding the roots and basic traits of HCT116 cells, such as their morphological features, genetic makeup, and cellular dimensions, is essential for researchers embarking on studies using this cell line.

The HCT116 VIM RFP reporter cell line carries a knock-in red fluorescent protein (RFP) reporter, which was integrated before the stop codon at the last exon of the endogenous vimentin (VIM) gene. Epithelial to mesenchymal transition (EMT) has been recognized to play an important role in cancer cell metastasis and drug resistance.

Part of: NCI-60 cancer cell line panel. Population: Caucasian. Doubling time: 17.1 hours (PubMed= 22628656); 22 hours (PubMed= 23546019); 25.02 hours (PubMed= 25944804); 36 hours (PubMed= 25984343); 18.14 +- 0.051 hours (PubMed= 32927768); ~25-48 hours (DSMZ=ACC-581); 17.4 hours (NCI-DTP=HCT-116); ~21 hours (PBCF).

2008年6月15日 · HCT116 human colon cancer cell line in this in vivo model system provides a tool to dissect the molecular mechanism involved in the metastatic cascade. This orthotopic model of colon cancer fulfills the rate limiting steps of local invasion and distant colony formation in the process of metastases.

HCT 116-Luc2 is a cell line exhibiting epithelial morphology that was isolated in 2018 from the colon of an adult male patient with carcinoma colorectal. This cell line can be used in assay development, and cancer research.

Here, we report the building of two QSAR studies using molecular and NMR descriptors for the prediction of anticancer activity against the human colon carcinoma HCT116 cell line, using the value of half maximal inhibitory concentration (IC 50).

HCT116 (ATCC® CCL-247 ™) is a human colorectal carcinoma cell line initiated from an adult male. The cells are adherent with an epithelial morphology. Following implantation into immunocompromised mice, the cells form primary tumors and distant metastases.

HCT116 BRCA2 -/- human colorectal carcinoma cell line was generated to study the role of BRCA2 in DNA repair, investigate the effects of BRCA2 mutations in a range of cancers, and identify additional functions of the BRCA2 gene.

HCT-116 cells harvested from tissue culture flasks are implanted into the subcutaneous space of the left flank of the mice. Resulting tumors are monitored by calipering twice weekly. Animal weights are measured three times weekly. Animal behaviour is monitored daily.