2024年12月25日 · GRK4 (G Protein-Coupled Receptor Kinase 4) is a Protein Coding gene. Diseases associated with GRK4 include Hypertension and Hypertension, Essential. Among its related pathways are Visual phototransduction and …

2008年3月17日 · GRK4 is the only GRK in which 4 splice variants (GRK4α, β, γ, and δ) have been identified in humans. 8,19,20 GRK4α, the full-length isoform, is most homologous with the other GRKs. GRK4β lacks exon 2, resulting in a 32-residue deletion that encompasses the phosphatidylinositol bisphosphate binding domain near the N terminus.

2021年4月7日 · Aims: G protein-coupled receptor kinase 4 (GRK4) has been reported to play an important role in hypertension, but little is known about its role in cardiomyocytes and myocardial infarction (MI). The goal of present study is to explore the role of GRK4 in the pathogenesis and progression of MI.

Abnormal G protein-coupled receptor kinase (GRK)-mediated regulation of GPCR function is involved in the pathogenesis of hypertension. Among the seven GRK subtypes, GRK4 has attracted attention because of its constitutive activity and tissue-specific expression.

Downregulation of G protein-coupled receptor kinase 4 protects against kidney ischemia-reperfusion injury. Comprehensive insights in GRK4 and hypertension: From mechanisms to potential therapeutics. Genetic variants of GRK4 influence circadian rhythm of blood pressure and response to candesartan in hypertensive patients.

2023年3月4日 · G protein-coupled receptor kinase 4 (GRK4) plays a vital role in essential hypertension and myocardial infarction, but its function in renal I/R injury remains undetermined.

2012年9月4日 · We tested the hypothesis that specific GRK4 polymorphisms affect the magnitude of BP response to the β-blocker atenolol and that these polymorphisms affect risk for experiencing adverse CV outcomes in participants treated with a β-blocker versus a calcium channel blocker (CCB) strategy.

2023年11月23日 · Our recent studies suggest that G protein-coupled receptor kinase 4 (GRK4) could be a molecule underlying pathological mechanism of hypertension and breast cancer.

GRK4 plays a role in BP homeostasis through phosphorylation of GPCRs important to BP regulation including dopamine receptors, and potentially β 1 -ARs, the key protein target of β-blockers.

The primary role of GRK4 is to phosphorylate G protein-coupled receptors (GPCR), which leads to desensitization of the G protein signaling mechanism while simultaneously recruiting β-arrestins and initializing the internalization of the receptor.