G protein-coupled receptor 1, also known as GPR1, is a protein that in humans is encoded by the GPR1 gene. [5] [6] GPR1 is a member of the G protein-coupled receptor family of …

A second chemerin receptor, G protein-coupled receptor 1 (GPR1) in mammals, binds chemerin with an affinity similar to CMKLR1; however, the function of GPR1 in mammals is essentially …

2024年10月28日 · Here, we report that GPR1 is capable of Gi signaling when stimulated with full-length chemerin or its C-terminal nonapeptide (C9, YFPGQFAFS). We present high-resolution …

2021年7月9日 · Here we demonstrate that GPR1 shows ligand-induced arrestin3 recruitment and internalization. The chemerin C-terminus triggers this activation by folding into a loop structure, …

Here we demonstrate that GPR1 shows ligand-induced arrestin3 recruitment and internalization. The chemerin C-terminus triggers this activation by folding into a loop structure, binding to …

2016年10月7日 · Chemerin is a small chemotactic protein originally identified as the natural ligand of CMKLR1. More recently, two other receptors, GPR1 and CCRL2, have been reported to …

When tested for pyruvic acid tolerance, GPR1 −/− exhibited reduced glucose-stimulated insulin levels, leading to an increase in blood glucose levels. Similar to CMKLR1, this suggests that …

2016年10月7日 · GPR1 is the closest homolog of CMKLR1, sharing more than 40% sequence identity with CMKLR1. Expression of GPR1 was reported in the central nervous system, skin …

We show that the C. albicans Gpr1 homologue is important for cell and colony morphology on solid media and provide evidence that it functions upstream in the cAMP–PKA pathway.

2023年11月27日 · We examined C9 signaling through GPR1 and found this receptor capable of Gi signaling but very weak β-arrestin signaling. Here we report high-resolution cryo-EM …