2024年12月25日 · GBP1 (Guanylate Binding Protein 1) is a Protein Coding gene. Diseases associated with GBP1 include Ulceroglandular Tularemia and Kaposi Sarcoma. Among its related pathways are Antiviral mechanism by IFN-stimulated genes and Cytokine Signaling in …

Interferon-induced guanylate-binding protein 1 is a protein that in humans is encoded by the GBP1 gene. [3][4] It belongs to the dynamin superfamily of large GTPases. [5] Guanylate binding protein expression is induced by interferon.

GBP1, the most widely studied GBP, has been studied for its antimicrobial properties. It can effectively polymerize and target the lipopolysaccharide cell wall of gram-negative bacteria.

2021年3月5日 · GBP1 represses the genomic transcription of VSV by competitively binding to the VSV-N substituting for the VSV-P, inhibits the nuclear delivery of KSHV virions by disrupting the actin filaments, and inactivating the viral particle of HEV by targeting the viral capsid protein to the lysosomal compartment.

Guanylate-binding protein 1 (GBP1) is a large GTPase of the dynamin superfamily involved in the regulation of membrane, cytoskeleton, and cell cycle progression dynamics. In many cell types, such as endothelial cells and monocytes, GBP1 expression ...

2022年2月22日 · GBP1 identifies gram-negative bacteria such as the enteric pathogen, Salmonella enterica serovar Typhimurium, that enter the cytoplasm of the host cell. GBP1 then quickly connects to LPS and stimulates the assembly of more …

2022年7月29日 · Here, we show that guanylate-binding proteins (GBPs) mediate pathogen-selective inflammasome activation. We show that mouse GBP1 and GBP3 are specifically required for inflammasome activation...

2019年7月1日 · GBP1 thus acts as a gatekeeper of cell death pathways, which respond specifically to infecting microbes. Our findings expand the immune roles of human GBPs in regulating not only pyroptosis, but also apoptosis.

2020年1月24日 · Guanylate-binding protein 1 (GBP1) is a large GTPase of the dynamin superfamily involved in the regulation of membrane, cytoskeleton, and cell cycle progression dynamics.

2020年7月22日 · Guanylate-binding proteins (GBPs) promote immune defenses against infectious agents. Two studies reveal that GBP1 directly binds to cytosolic lipopolysaccharide (LPS), bringing caspase-4 to the...