Transcription factor GATA-6, also known as GATA-binding factor 6 (GATA6), is protein that in humans is encoded by the GATA6 gene. [5] The gene product preferentially binds (A/T/C)GAT(A/T)(A) of the consensus binding sequence .

2024年12月25日 · GATA6 (GATA Binding Protein 6) is a Protein Coding gene. Diseases associated with GATA6 include Heart Defects, Congenital, And Other Congenital Anomalies and Atrioventricular Septal Defect 5. Among its related pathways are …

2025年3月4日 · In this study, we evaluated the prognostic utility of GATA6 immunohistochemistry (IHC), measured with digital assistance, in the ESPAC-4 trial of adjuvant chemotherapy for pancreatic cancer, 2 which defined one of the current standard-of-care adjuvant therapies.

2025年2月7日 · GATA6, a pioneer factor during endoderm differentiation, has been suggested as a key regulator for CRC tumorigenesis and progression and is associated with worse prognoses (23–28). For example, Tsuji et al. suggested a potential link between GATA6 and the expression of CRC stem cell marker LGR5.

GATA6 regulates aging of human mesenchymal stem/stromal cells. GATA6 Expression Distinguishes Classical and Basal-like Subtypes in Advanced Pancreatic Cancer. The value of GATA6 immunohistochemistry and computer-assisted diagnosis to predict clinical outcome in advanced pancreatic cancer.

Northwestern Medicine scientists have discovered that inhibiting the GATA6 protein in mouse models of colon cancer reduced tumor growth and improved survival, underscoring the potential of a new therapeutic target for colon cancer, according to …

We found that disruption of the pericardial cavity accelerated maladaptive post-MI cardiac remodeling. Gata6 + macrophages in mouse pericardial fluid contributed to the reparative immune response. Following experimental MI, these macrophages invaded the epicardium and lost Gata6 expression but continued to perform anti-fibrotic functions.

This study underscores the broad phenotypic spectrum by presenting two patients with de novo GATA6 mutations, both exhibiting complex cardiac defects, pancreatic, and other abnormalities. Furthermore, we provided a detailed overview of all published human genetic variation in/near GATA6 published to date and the associated phenotypes (n = 78).

To delineate core downstream genes, pathways, and functions in gastric cancer, we examined genome-wide GATA6 occupancy in relation to GATA6-dependent gene expression in cell lines and GATA6-associated gene expression (synexpression) in human tumor samples.

2025年2月24日 · GATA6, known for its role in regulating gene expression during development and cellular differentiation, has emerged as a crucial factor in the progression of PDA, influencing various signaling pathways that govern tumor behavior.