2009年8月4日 · Fibroblast growth factor (FGF) receptor substrate 2 (FRS2), an adapter protein, has been identified as a major downstream mediator of FGFR signaling. It is thought to play a critical...

2024年12月25日 · Complete information for FRS2 gene (Protein Coding), Fibroblast Growth Factor Receptor Substrate 2, including: function, proteins, disorders, pathways, orthologs, and expression.

By using the Frs2α null mouse embryonic fibroblast (MEF) in conjunction with inhibitors to multiple signaling pathways, here we report that the FGF signaling axis activates mTOR via the FGF receptor substrate 2α (FRS2α)-mediated PI3K/Akt pathway, and suppresses autophagy activity in …

2025年2月9日 · Results identify FRS2 as an oncogene in a subset of high-grade serous ovarian cancers that harbor FRS2 amplifications. Increased expression of FRS2alpha (and FGFR1) was associated with decreased progression-free survival among patients with metastatic renal cell carcinoma treated with sorafenib.

FRS2 binds to unphosphorylated peptides in the juxamembrane domain of the FGF receptor. It binds to tyrosine phosphorylated peptides in RET and TrkA, and the binding sites are shared with those of other PTB domain‐containing signaling proteins.

The docking protein FRS2 was implicated in the transmission of extracellular signals from the fibroblast growth factor (FGF) or nerve growth factor (NGF) receptors to the Ras/mitogen-activated protein kinase signaling cascade.

2013年2月15日 · Fibroblast growth factor (FGF) receptor (FGFR) substrate 2 (FRS2) is an adaptor protein that plays a critical role in FGFR signaling. FRS2 is located on chromosome 12q13-15 that is frequently amplified in liposarcomas.

FRS2 stands for fibroblast growth factor (FGF) receptor substrate 2. The FGF receptor substrate 1 is phospholipase (PLC) γ, which was identified as the first substrate of FGF receptor tyrosine kinases (Gotoh et al. 2004).

By protein purification, sequence analysis, PCR of cDNA prepared from mRNA isolated from NIH 3T3 cells, and screening of a Swiss 3T3 cell cDNA library, they isolated a full-length cDNA encoding FRS2. The deduced 508-amino acid protein has a predicted molecular mass of 56.8 kD.

The FRS2 family of adaptor/scaffold proteins has two members, FRS2alpha and FRS2beta. Both proteins contain N-terminal myristylation sites for localization on the plasma membrane and a PTB domain for binding to limited species of receptor tyrosine kinases (RTKs), including the FGF receptor, the neur …