FOXP3 - Wikipedia
Foxp3 is a specific marker of natural T regulatory cells (nTregs, a lineage of T cells) and adaptive/induced T regulatory cells (a/iTregs), also identified by other less specific markers …
FOXP3 and its role in the immune system - PubMed
Both naive and memory FOXP3 T-cells are required for effective maintenance of tolerance and prevention of autoimmune diseases throughout the body. Many factors such as cytokines and …
FOXP3 Gene - GeneCards | FOXP3 Protein | FOXP3 Antibody
2024年12月25日 · FOXP3 (Forkhead Box P3) is a Protein Coding gene. Diseases associated with FOXP3 include Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked and …
The regulation of immune tolerance by FOXP3 - Nature
2017年7月31日 · This Review considers how forkhead box protein P3 (FOXP3) — the key transcription factor of regulatory T (Treg) cells — is regulated both at the transcriptional level …
FOXP3 gene - MedlinePlus
The FOXP3 gene provides instructions for producing the forkhead box P3 (FOXP3) protein. The FOXP3 protein attaches (binds) to specific regions of DNA and helps control the activity of …
Regulatory T Cells and Foxp3 - PMC - PubMed Central (PMC)
Regulatory T (Treg) cells play central role in regulation of immune responses to self antigens, allergens, and commensal microbiota as well as immune responses to infectious agents and …
FOXP3 - an overview | ScienceDirect Topics
FOXP3 is known to both activate and repress target genes by epigenetically regulating histone modifications of target promoters. In this review, we first focus on germline mutations found in …
FOXP3 recognizes microsatellites and bridges DNA through ...
2023年11月29日 · FOXP3 uses the forkhead domain to form a higher-order multimer after binding to TnG repeat microsatellites.
Regulatory T Cells: The Many Faces of Foxp3 - PMC
Regulatory T (Treg) cells expressing the transcription factor forkhead box P3 (Foxp3) play a requisite role in the maintenance of immunological homeostasis and prevention of peripheral …
Genome-wide CRISPR screen in human T cells reveals regulators of FOXP3
3 天之前 · To uncover putative regulators of FOXP3 expression, we developed a pooled CRISPR-screening platform in primary human CD4 + T cells undergoing iT reg differentiation (Fig. …