2024年12月25日 · FCRL5 (Fc Receptor Like 5) is a Protein Coding gene. Diseases associated with FCRL5 include Hairy Cell Leukemia and Lymphoma. Among its related pathways is Extrafollicular and follicular B cell activation by SARS-CoV-2. …

2024年1月12日 · Fc receptor-like 5 (FCRL5) is a protein marker with considerably upregulated expression in MM and has emerged as a promising target for CAR-T cell therapeutic interventions, offering an...

2019年4月30日 · In infected mice, FCRL5 is expressed on the majority of antigen-specific germinal-center-derived memory B cells (MBCs). Upon challenge, FCRL5 + MBCs rapidly give rise to antibody-producing cells expressing additional atypical markers, demonstrating functionality in vivo.

2025年2月8日 · FCRL5 is a new type of receptor that recognizes intact IgG, possibly enabling B cells to sense Ig quality. Recognition of undamaged IgG molecules by FCRL5 could allow B cells to engage recently produced Abs. FcRL5 binds all …

By generating B cell-specific Fcrl5 transgenic mice, we demonstrated that Fcrl5 overexpression in B cells caused systemic autoimmunity with age. Additionally, Fcrl5 upregulation in B cells exacerbated the systemic lupus erythematosus-like disease model.

2025年1月4日 · Title: FCRL5 Delineates Functionally Impaired Memory B Cells Associated with Plasmodium falciparum Exposure. FCRL5 is a new type of receptor that recognizes intact IgG, possibly enabling B cells to sense Ig quality.

2023年11月2日 · We tested four FCRL5 CAR-T (4-1BB CD3z) predicted to target distinct D9 epitopes and observed high cytolytic activity in killing assays using OPM2-CG-FCRL5 target cells. We tested each in vivo by injecting NSG mice in with OPM2-CG and 18 days later treated with 2x10 6 FCRL5 CAR-T.

Fc receptor-like 5 (FcRL5/FcRH5/IRTA2/CD307) is a surface protein expressed selectively on B cells and plasma cells. We found that FcRL5 was expressed at elevated levels on the surface of plasma cells from the bone marrow of patients diagnosed with multiple myeloma.

FCRL5+ atypical memory B cells (MBCs) expand in many chronic human diseases. Using tetramers to track rare antigen-specific cells, Kim et al. show that FCRL5+ MBCs are mature, optimally responsive cells that arise not only in response to infection and protein immunization in mice but also to immunization in humans.

Fc receptor-like (FCRL) proteins are novel regulators of the B cell response to antigen. Human FCRL5 binds intact IgG and modifies the strength of antigen receptor (BCR) signaling. Altering FCRL5 expression could therefore regulate the B cell response to antigen.