The high affinity IgE receptor plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma.

2024年12月25日 · High-affinity receptor for immunoglobulin epsilon/IgE. Mediates IgE effector functions in myeloid cells. Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation.

Data indicate that antigen (Ag) targeting to FcepsilonRI inhibits the development of Ag-specific T cell immunity and induces T cell tolerance. FCER1A expressing dendritic cells and monocytes but not basophils, significantly contribute to serum hIgE clearance.

The high-affinity IgE receptor, also known as FcεRI, or Fc epsilon RI, is the high- affinity receptor for the Fc region of immunoglobulin E (IgE), an antibody isotype involved in allergy disorders and parasite immunity. FcεRI is a tetrameric receptor complex that binds Fc portion of the ε heavy chain of IgE. [1] .

FcεRI, a high-affinity IgE receptor, deciphers the Ag–IgE interaction and drives allergic responses. FcεRI clustering is essential for signal transduction and, therefore, determines the quality of MC responses.

RNA specificity category based on RNA sequencing data from cancer cell lines in the Human Protein Atlas grouped according to type of cancer. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.

2025年1月4日 · Gene target information for FCER1A - Fc epsilon receptor Ia (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

2025年2月8日 · A Co-Expressed Natural Antisense RNA FCER1A-AS Controls IgE-Dependent Immunity by Promoting Expression of FcepsilonRIalpha. IRF3 Activation in Mast Cells Promotes FcepsilonRI-Mediated Allergic Inflammation.

View mouse Fcer1a Chr1:173048851-173054781 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression

2019年12月9日 · The mRNA expression levels of FCER1A and FCER2 were significantly lower in KD patients than in non-febrile controls and then rose following treatments with intravenous immunoglobulin (IVIG)....

2016年9月14日 · The protein encoded by the FCER1A gene represents the alpha subunit. [provided by RefSeq, Aug 2011] Enables IgE binding activity and high-affinity IgE receptor activity. Involved in leukocyte degranulation; type 2 immune response; and type I hypersensitivity. Located in cell surface and plasma membrane. Biomarker of asthma and rhinitis.

In this study, we discovered that a natural antisense transcript, FCER1A -AS, is co-expressed with the sense transcript. The presence of FCER1A -AS is essential for sense transcript expression in mast cells and basophils, but not for the differentiation of these cells through cis -regulation.

2020年11月4日 · Importantly, we have confirmed the association of the allergy-relevant SNP rs2427837 with FCER1A and believe that targeting FCER1A in monocytes and pDCs might constitute a novel option to reduce allergen-specific responses.

2024年8月9日 · Title: A Co-Expressed Natural Antisense RNA FCER1A-AS Controls IgE-Dependent Immunity by Promoting Expression of FcεRIα. IRF3 Activation in Mast Cells Promotes FcepsilonRI-Mediated Allergic Inflammation.

2023年11月20日 · First, in a cohort of patients with peripheral blood hypereosinophilia, we found low but detectable expression of both FCER1A and FCER1G mRNAs, which encode for FcεRIα and FcεRIγ (a component of other receptors besides FcεRI), respectively (Fig 1, A).

2023年11月23日 · Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. An internal error has occurred that prevents Sequence Viewer from displaying. publications in PubMed explicitly cited by the gene record in OMIM.

High-affinity receptor for immunoglobulin epsilon/IgE. Mediates IgE effector functions in myeloid cells. Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that …

2008年8月22日 · By examining >11,000 German individuals from four independent population-based cohorts, we show that functional variants in the gene encoding the alpha chain of the high affinity receptor for IgE (FCER1A) on chromosome 1q23 are …

Mast cells and basophils express both the heterotetrameric high-affinity IgE receptor, FCER1, which is important in allergic diseases, and FCGR2B (604590), a low-affinity IgG receptor.

RefSeq summary [FCER1A] The IgE receptor plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma.