Galactoside 2-alpha-L-fucosyltransferase 2 is an enzyme that in humans is encoded by the FUT2 gene. [5][6] It affects the secretor status of ABO antigens. [7]

2024年12月25日 · FUT2 (Fucosyltransferase 2 (H Blood Group)) is a Protein Coding gene. Diseases associated with FUT2 include Vitamin B12 Plasma Level Quantitative Trait Locus 1 and Bombay Phenotype. Among its related pathways are superpathway of glycosphingolipids biosynthesis and Sphingolipid metabolism.

In human, FUT2 gene encodes an enzyme known as Galactoside 2-alpha-L-fucosyltransferase 2 which is responsible for secretor status of ABO antigens [3]. Other names for FUT2 are B12QTL1, SE, Se2, SEC2, and sej [4]. The size of FUT2 gene is 9,980 bases with Plus strand orientation and, present on chromosome 19q13.33.

2016年2月9日 · The FUT2 gene secretions influence the kind and amount of beneficial bacteria that grow in the digestive tract. The main type affected bifidobacteria, which are probiotics that …

基于IBD中 Fut2和α-1,2-岩藻糖基化表达水平的降低，假设Fut 2在结肠炎中具有重要的功能相关性。 为了评估Fut2在结肠炎中的作用，通过在饮用水中给予3% DSS 7天，在WT和Fut2 IEC小鼠中诱导结肠炎。 当用DSS处理时，Fut2 IEC小鼠表现出比WT小鼠更高的死亡率 (图2b)，伴随着结肠长度的减少 (图2a)。 并且Fut2 IEC小鼠的疾病活动评分比DSS组的WT小鼠高得多 (图2c)。 此外，这伴随着较短的结肠长度 (图2d，e)。 与临床症状一致，Fut2 IEC小鼠结肠切片中更严重的腺体 …

The fucosyltransferase 2 gene (FUT2) mediates the synthesis of histoblood group antigens (HBGA) that occur in vivo from multiple organs, particularly on the surface of intestinal epithelial cells and body fluids. To date, many studies have ...

Gene ID: 2524, updated on 8-Feb-2025. This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. The encoded protein is important for the final step in the soluble ABO blood group antigen synthesis pathway. It is also involved in cell-cell interaction, cell surface expression, and cell proliferation.

该基因是编码半乳糖苷 2-L-岩藻糖基转移酶的两个基因之一。 编码的蛋白质对于可溶性 ABO 血型抗原合成途径的最后一步很重要。 它还参与细胞间相互作用、细胞表面表达和细胞增殖。 该基因的突变是导致 H-Bombay 血型的原因，其中红细胞缺乏 H 抗原。 [RefSeq 提供，2022 年 5 月] This gene is one of two encoding the galactoside 2-L-fucosyltransferase Enzyme. The encoded protein is important for the final step in the soluble ABO blood group antigen synthesis pathway.

2020年10月8日 · The FucosylTransferase 2 (FUT2) gene is associated with the synthesis of fucosyltransferase 2. This enzyme found to attach the bacterium Helicobacter pylori to the gastric mucosa, which affects the absorption of vitamin B12 in the gut.

2 天之前 · The normal activity of FUT2 has been found to be disrupted by non-synonymous single nucleotide polymorphisms (nsSNPs) in its gene.