Fms-related tyrosine kinase 4, also known as FLT4, is a protein which in humans is encoded by the FLT4 gene. [5] [6] This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium.

2024年12月25日 · FLT4 (Fms Related Receptor Tyrosine Kinase 4) is a Protein Coding gene. Diseases associated with FLT4 include Lymphatic Malformation 1 and Congenital Heart Defects, Multiple Types, 7. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.

Rare, deleterious genetic variants in FLT4 are associated with Tetralogy of Fallot (TOF), the most common cyanotic congenital heart disease. The distinct genetic variants in FLT4 are also an established cause of Milroy disease, the most prevalent form of primary hereditary lymphoedema.

The FLT4 gene provides instructions for making a protein called vascular endothelial growth factor receptor 3 (VEGFR-3), which regulates the development and maintenance of the lymphatic system. Learn about this gene and related health conditions.

our findings contribute to the putative targets in which the FLT4 gene mutation was found to have a significant role in lymphatic filariasis, while FOXC2 and FLT4 SNP interactions need to be further elucidated at a functional level.

This study presents FLT4 mutation findings from whole-exome sequencing (WES) analysis of a cohort of 29 MD patients. The patients underwent indocyanine green (ICG) lymphography examination to localize and characterize lymphatic defects in their affected limbs.

2023年7月25日 · VEGFR3 (also known as FLT4) has a similar structure but is proteolytically cleaved in the extracellular domain during synthesis, resulting in the generation of a disulfide bridge between the two...

The results suggested that FLT4 is a marker for lymphatic vessels and some high endothelial venules in human adult tissues. They also supported the theory of the venous origin of lymphatic vessels. Vascular endothelial growth factor is a key regulator of blood vessel development in embryos and angiogenesis in adult tissues.

2023年11月23日 · This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008]

2021年6月15日 · Jerafi-Vider et al. report a mechanism of endothelial cell sprouting, whereby the mitogenic VEGFC/FLT4/ERK signaling pathway induces p53-, p21-, and p27-mediated cell-cycle arrest, conferring angiogenic potential.