Fibroblast growth factor 4 is a protein that in humans is encoded by the FGF4 gene. [5][6] The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family.

2024年12月25日 · FGF4 (Fibroblast Growth Factor 4) is a Protein Coding gene. Diseases associated with FGF4 include Embryonal Carcinoma and Germ Cell Cancer. Among its related pathways are Downstream signaling of activated FGFR2 and Apoptotic Pathways in …

The mitogenic and cytoprotective properties of FGF7 are already being put to advantageous use in the clinic. Other FGFs, including FGF1, FGF2 and FGF4, have been tested in clinical trials and may eventually be used to treat cardiovascular disease.

FGF/FGFR signaling governs fundamental cellular processes such as cell survival, proliferation, migration, differentiation, embryonic development, organogenesis, tissue repair/regeneration, and metabolism.

FGF4 ameliorates the liver inflammation by reducing M1 macrophage polarization in experimental autoimmune hepatitis. FGF4 Promotes Skin Wound Repair through p38 MAPK and GSK3beta-Mediated Stabilization of Slug. FGF4 improves hepatocytes ferroptosis in autoimmune hepatitis mice via activation of CISD3.

2025年1月4日 · Title: The oncoprotein HBXIP up-regulates FGF4 through activating transcriptional factor Sp1 to promote the migration of breast cancer cells. Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity.

Fgf4, also called “human stomach cancer transforming factor-1” (hst-1), was discovered when DNA from stomach tissues was shown to induce the malignant transformation of fibroblasts. The same oncogene was isolated by transfection of Kaposi sarcoma DNA and is therefore also called “kaposi sarcoma Fgf ” ( kFgf ).

2024年9月18日 · Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity. Fibroblast growth factor 4 and its novel splice isoform have opposing effects on the maintenance of …

2015年10月13日 · Grafting gremlin-expressing cells into ld mutant limb buds rescued Fgf4 expression and restored the Shh/Fgf4 feedback loop. Analysis of Shh-null mutant embryos revealed that Shh signaling is required for maintenance of gremlin and formin (FMN1; 136535), the gene disrupted by the ld mutations.

Fibroblast growth factor 4 (FGF4) is a multipotent growth factor and is highly expressed in various human cancers. However, the regulatory mechanism of FGF4 in breast cancer remains poorly understood.

The Fgf1, Fgf4, Fgf7, Fgf8, and Fgf9 subfamily genes encode secreted canonical FGFs, which bind to and activate FGFRs with heparin/HS as a cofactor. The Fgf15/19 subfamily members encode endocrine FGFs, which bind to and activate FGFRs with the …

Our study identifies FGF4 as a stress-responsive regulator of liver pathophysiology that acts through an FGFR4-AMPK-Caspase 6 signal pathway, shedding light on strategies for treating NAFLD and associated liver pathologies.

2002年12月15日 · We identify the Fgf4 gene as a direct transcriptional target for LEF1 and show that beads soaked with recombinant FGF4 protein can fully overcome the developmental arrest of Lef1 (-/-) tooth germs.

2025年2月8日 · FGF4 alleviates hyperglycemia in diabetes and obesity conditions. The spontaneous mouse mutant low set ears (Lse) is caused by tandem duplication of Fgf3 and Fgf4. Multi-level Fgf4- and apoptosis-dependent regulatory mechanism ensures the plasticity of ESC-chimaeric mouse embryo.

Fibroblast growth factors (FGFs) signal through FGF receptor tyrosine kinases to regulate a wide range of biological processes during development and adulthood. FGF receptors (FGFRs) are...

Fibroblast Growth Factor-4 (FGF4) is a 19 kDa protein, belonging to the FGF family of proteins. Fibroblast growth factors (FGF) are glycoproteins concealed in the extracellular matrix and cell surface. There are around 22 different types of FGFs known.

2013年8月13日 · Exogenous addition of FGF4 stimulated proliferation of mouse ESCs (mESCs), as proven by the increases in DNA synthesis and cell cycle regulatory protein induction. These increases were almost completely inhibited by pre-treating cells with anti-FGF4 antibody.

FGF4 is one of the most representative factors and plays a role in cell growth of the embryonic trophoblast in embryo implantation. FGF Receptor-1 and FGFR-2 are increasingly prominent in breast cancer.

Fibroblast growth factor 4 (FGF4) is a gene that encodes a protein with mitogenic activity that functions in embryonic development and cell growth. Missense, nonsense, and silent mutations are observed in cancers such as intestinal cancer, ovarian cancer, and skin cancer.

2022年3月4日 · Significant changed FGF4 was selected, engineered, purified, and used to treat GDM mice in order to examine whether it can regulate the adverse metabolic phenotypes of the diabetic mice and protect their fetus.

FGF-4 is encoded by the heparin-binding secretory transforming gene (hst). Like FGF-2, hst/FGF-4 stimulates pituitary prolactin secretion, but it also stimulates lactotroph proliferation and development of prolactinomas.