2024年12月25日 · FADS1 (Fatty Acid Desaturase 1) is a Protein Coding gene. Diseases associated with FADS1 include Lipid Metabolism Disorder and Vitelliform Macular Dystrophy. Among its related pathways are docosahexaenoate biosynthesis IV (4-desaturase, mammals) and Fatty acid metabolism.

Desaturase enzymes (such as those encoded by FADS1) regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5 -like domain and a C-terminal multiple membrane-spanning desaturase portion ...

2023年4月11日 · Here they show that FADS1-AA axis modulates the intestinal microecology by enriching gram-negative bacteria in CRC and that the altered microecology accelerates the conversion of AA to PGE2 ...

fads1（脂肪酸去饱和酶1）作为pufa代谢的关键限速酶，可以将dgla（二高-γ-亚麻酸）催化成aa（花生四烯酸）。既往研究发现，fads1在许多癌症中的表达失调，而敲低fads1不仅可以抑制肿瘤的生长和迁移，而且还可以增强化疗药物的细胞毒性。

fads 家族成员被认为是由 n 端细胞色素 b5 样结构域和 c 端多跨膜去饱和酶部分组成的融合产物，两者都具有保守的组氨酸基序特征。该基因在 11q12-q13.1 与家族成员 fads1 和 fads2 聚类；该簇被认为是基于其相似的外显子/内含子组织从基因复制进化而来的。

2025年2月8日 · Title: FADS1-arachidonic acid axis enhances arachidonic acid metabolism by altering intestinal microecology in colorectal cancer. Placental expression of Fatty Acid Desaturases 1, 2 and 3 in selected pregnancy pathologies.

2022年8月15日 · Fatty Acid Desaturase-1 (FADS1) or delta 5 desaturase (D5D) is a rate-limiting enzyme involved in the biosynthesis of long-chain polyunsaturated fatty acids (LC-PUFAs), i.e., arachidonic acid (ARA) and eicosapentaenoic (EPA). These LC-PUFAs and their metabolites play essential and broad roles in can …

The FADS1 gene codes for the fatty acid delta-5 desaturase, a key enzyme in the metabolism of long-chain polyunsaturated omega-3 and omega-6 fatty acids. From: Current Opinion in Biotechnology , 2013

2017年10月26日 · The main findings of the current study are (1) Fads1 is a major contributor to diet-driven enrichment of PUFAs in membrane phospholipids; (2) Fads1 loss of function results in diminished levels of AA-, EPA-, and DHA-derived proresolving lipid mediators; (3) Fads1 knockdown promotes hepatic inflammation in a diet-specific manner; (4) Fads1 ...

FADS1 (Fatty Acid Desaturase 1) Genotype Associates With Aortic Valve FADS mRNA Expression, Fatty Acid Content and Calcification. Fatty acid desaturase activity in mature red blood cells and implications for blood storage quality.