Here we confirmed pervasive phenotypic, functional, and transcriptional differences between memory and exhausted antigen-specific CD8+ T cells in human hepatitis C virus (HCV) infection before and after treatment.

2019年2月18日 · Here we show that such therapy acts on a specific subpopulation of exhausted CD8 + tumor-infiltrating lymphocytes (TILs). Dysfunctional CD8 + TILs possess canonical epigenetic and...

Leveraging several single-cell RNA sequencing datasets, we report greater CD8 + exhausted T cells in human pediatric low-grade gliomas (LGGs) relative to adult and pediatric HGGs.

Functional enrichment analysis revealed that the evolutionary process of exhausted T cells mainly contained the pathway of cadherin binding, proteasome, cell cycle, and T cell receptor...

2021年7月26日 · Here we confirmed pervasive phenotypic, functional and transcriptional differences between memory and exhausted antigen-specific CD8 + T cells in human hepatitis C virus (HCV) infection...

2023年1月2日 · Using single-cell RNA and TCR sequencing, we traced the clonal expansion and differentiation of CD8+ T cells during chronic LCMV infection. We identified immense clonal and phenotypic diversity, including a subset termed intermediate cells.

Beltra et al. define a hierarchical developmental pathway for CD8 + T cell exhaustion, revealing four stages and multistep transcriptional and epigenetic dynamics underlying subset transitions and subset-associated biological changes. Chronic viral infections (HIV, HCV, HBV) and cancers subvert CD8 + T cell differentiation toward exhaustion.

2020年9月8日 · Here, we characterize the in vivo TCR signaling of virus-specific exhausted CD8 + T cells in a mouse model, leveraging TCR signaling reporter mice in combination with transcriptomics. In vivo signaling in exhausted cells is low, in contrast to their in vitro signaling potential, and despite antigen being abundantly present.

Here, we discuss recent advances in our understanding of exhausted CD8 + T cell heterogeneity as well as the potential differentiation trajectories that exhausted T cells follow during chronic infection and/or cancer.

2023年12月12日 · Rewiring exhausted CD8 + T (Tex) cells toward functional states remains a therapeutic challenge. Tex cells are epigenetically programmed by the transcription factor Tox.