Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound protein that in humans is encoded by the ERBB3 gene. ErbB3 is a member of the epidermal growth factor receptor (EGFR/ERBB) family …

2024年12月25日 · ERBB3 (Erb-B2 Receptor Tyrosine Kinase 3) is a Protein Coding gene. Diseases associated with ERBB3 include Lethal Congenital Contracture Syndrome 2 and Visceral Neuropathy, Familial, 1, Autosomal Recessive. Among its related pathways are GPCR Pathway and Prolactin Signaling.

ERBB3, a member of the epidermal growth factor receptor (EGFR) family, is unique in that its tyrosine kinase domain is functionally defective. It is activated by neuregulins, by other ERBB and nonERBB receptors as well as by other kinases, and by novel mechanisms.

2019年9月13日 · In this review, we discuss the evidence presenting ERBB3 somatic mutations as potential tumoral drivers. We then show that ERBB3 mutations are not uncommon in many cancer types.

2024年9月1日 · ERBB3 demonstrates the ability to either enhance or decrease ER signalling. The outcomes are likely affected by the balance between ERα and ERβ levels and the interactions of their downstream signalling regulators. These complex associations might explain the diverse therapeutic responses to endocrine therapy.

In this review, we discuss the unique structural and functional features of ERBB3 and how this information is being used to develop effective new therapeutic agents that target ERBB3 in human cancers.

2013年5月13日 · Here, we report the identification of ERBB3 somatic mutations in ∼11% of colon and gastric cancers. Functional characterization of the ERBB3 mutants show that, with ERBB2, they promote oncogenic signaling in a ligand-independent manner.

ErbB3 has a role in cell proliferation in ovarian cancer. HER-3 expression is correlated with better prognosis in neuroendocrine cancer; erbB3 immunoreactivity was prominent in CD133-positive putative tumor stem cells.

2008年4月11日 · ERBB3, a member of the epidermal growth factor receptor (EGFR) family, is unique in that its tyrosine kinase domain is functionally defective. It is activated by neuregulins, by other...

2009年6月18日 · In this Review we re-evaluate the role of two important family members, ERBB2 (also known as HER2) and ERBB3 (also known as HER3), and explore the mechanisms of action and preclinical and...