2024年12月25日 · EPHA2 (EPH Receptor A2) is a Protein Coding gene. Diseases associated with EPHA2 include Cataract 6, Multiple Types and Aniridia. Among its related pathways are GPCR Pathway and ERK Signaling.

2020年8月18日 · Overall, EphA2 represents a potential target for treating malignant tumors. Ephrin receptors (Eph) represent the most important class of receptor tyrosine kinases (RTKs) [1]. EphA1, the firstly described Eph receptor, was identified in liver cancer cells while screening for RTKs in 1987 [2].

2024年11月13日 · In this review, we summarize the main mechanisms underlying EphA2 dysregulation in cancer, highlighting its molecular complexity. Then, we analyze therapies that have been developed over time to counteract its action.

2020年8月18日 · The tyrosine kinase EphA2, which belongs to the family of Eph receptors, is highly produced in tumor tissues, while found at relatively low levels in most normal adult tissues, indicating its potential application in cancer treatment.

2018年2月22日 · The EphA2 receptor tyrosine kinase is capable of activating multiple diverse signaling pathways with roles in processes such as tissue homeostasis and cancer.

2021年3月8日 · This review will summarize preclinical studies supporting the oncogenic role of EphA2 in breast cancer, lung cancer, glioblastoma, and melanoma, while delineating the differing roles of canonical...

Recent analyses have revealed that the EphA2 receptor is a key modulator for a wide variety of cellular functions. This review focuses on the roles of EphA2 in both development and disease. Keywords: EphA2, ephrin, development, cataract, kidney, …

2021年4月20日 · Ephrin type-A receptor 2 (EphA2), a receptor tyrosine kinase, is overexpressed in human breast cancers often linked to poor patient prognosis. Accumulating evidence demonstrates that EphA2 plays important roles in several critical processes associated with malignant breast progression, such as proli …

EphA2 Is a Lung Epithelial Cell Receptor for Pneumocystis beta-Glucans. EPHA2 mediates PDGFA activity and functions together with PDGFRA as prognostic marker and therapeutic target in glioblastoma. CircPAG1 Inhibits the High Glucose-Induced Lens Epithelial Cell Injury by Sponging miR-630 and Upregulating EPHA2.

2021年12月2日 · EphA2 promotes cancer malignancy through a poorly understood non-canonical form of signaling involving serine/threonine phosphorylation of the linker connecting its kinase and SAM domains.