Drosha is a Class 2 ribonuclease III enzyme [5] that in humans is encoded by the DROSHA (formerly RNASEN) gene. [6][7][8] It is the primary nuclease that executes the initiation step of miRNA processing in the nucleus. It works closely with DGCR8 and in correlation with Dicer.

2024年12月24日 · DROSHA (Drosha Ribonuclease III) is a Protein Coding gene. Diseases associated with DROSHA include Hereditary Breast Ovarian Cancer Syndrome and Lynch Syndrome 5. Among its related pathways are Formation of HIV elongation complex in the absence of HIV Tat and Translational Control.

Drosha is the catalytic center of the microprocessor and has two RNase-III domains that make up a catalytic site with each domain making one of the two cuts necessary to excise the pre-miRNA. Drosha excises the pre-miRNA from the pri-miRNA by cutting at the base of the dsRNA stem–loop of the pre-miRNA [82].

2016年4月29日 · A recent study by Kwon et al. in Cell reveals the structure of a DROSHA construct in complex with the C-terminal region of DGCR8, thereby unveiling the topology and interactions between...

DROSHA is the catalytic subunit of the Microprocessor complex, which initiates microRNA (miRNA) maturation in the nucleus by recognizing and cleaving hairpin precursors embedded in primary transcripts. However, accumulating evidence suggests that ...

2025年3月20日 · Originally described in Drosophila, but the human homologue is ubiquitiously expressed in tissues. Drosha interacts with the double-stranded-RNA-binding protein DGCR8 (deleted in di George syndrome) and they are both present within …

2012年7月20日 · DROSHA is a nuclear RNase III enzyme responsible for cleaving primary microRNAs (miRNAs) into precursor miRNAs and thus is essential for the biogenesis of canonical miRNAs.

2025年2月20日 · Depletion of drosha ribonuclease III (Drosha) significantly reduces DNA repair by both homologous recombination (HR) and non-homologous end joining (NHEJ). Increased Drosha expression was found in chronic lymphocytic …

2016年1月14日 · The heretofore-elusive structure of DROSHA provides insights into how nascent microRNAs are recognized and cleaved in their initial processing step and reveals an unexpected similarity between DROSHA and DICER, the enzyme …

2014年11月24日 · The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA) processing in the nucleus (Lee et al., 2003). By database searching and screening of a human liver cDNA library, Wu et al. (2000) cloned a …