2017年8月8日 · DNAJB9 immunohistochemistry is sensitive and specific for FGN. Incorporation of this novel immunohistochemical biomarker into clinical practice will now allow more rapid and accurate diagnosis of this disease.

DNAJB9 was first identified in 2002 as a ubiquitous protein preferentially expressed in endoplasmic reticulum-rich cells (e.g., liver, placenta, and kidneys) [12,13]. As a consequence, DNAJB9 IHC could be positive in normal tissue showing a …

2024年12月24日 · DNAJB9 (DnaJ Heat Shock Protein Family (Hsp40) Member B9) is a Protein Coding gene. Diseases associated with DNAJB9 include Immunoglobulin Heavy Chain Amyloidosis and Gestational Ovarian Choriocarcinoma. Among its related pathways are Unfolded Protein Response (UPR) and Cellular responses to stimuli.

2019年2月15日 · What is DNAJB9 – (DNAJ homolog subfamily B member 9) and how does it help us? DNAJB9 belongs to a family of proteins that function as “co-chaperones” to heat-shock protein 70 (hsp-70). It is expressed in all healthy tissues and is localised to endoplasmic reticulum (ER) and is upregulated by ER stress, nitric oxide, and other inflammatory ...

DnaJ homolog subfamily B member 9 is a protein that in humans is encoded by the DNAJB9 gene. [5] [6] [7]

DNAJB9 tissue assays, paraffin immunofluorescence studies, and IgG subclass testing demonstrate that FGN is distinct from other glomerular diseases with organized deposits and highlight FGN morphologic variants.

DNAJB9 suppresses the metastasis of triple-negative breast cancer by promoting FBXO45-mediated degradation of ZEB1. DNAJB9-positive monotypic fibrillary glomerulonephritis is not associated with monoclonal gammopathy in the vast majority of patients.

2021年5月8日 · In this study, we found that ectopic restoration of DNAJB9 inhibits the migration, invasion, in vivo metastasis, and lung colonization of triple-negative breast cancer (TNBC) cells.

In this study, we demonstrate that DNAJB9 protein expression in glomeruli of patients with fibrillary GN is not dependent on glomerular transcriptional upregulation of DNAJB9.

2020年7月22日 · The current report describing cases of DNAJB9-positive immunoglobulin-negative FGN favors that DNAJB9 (not IgG) is critical for FGN fibril formation, and that in rare cases, DNAJB9 deposition does not trigger an autoimmune response or triggers a minimal response below the level of detection by the commercially available immunofluorescence ...