DICER is a multidomain endonuclease that belongs to the fourth class of type III ribonuclease (RNase III) enzymes. DICER is encoded by a single gene in vertebrates and C. elegans, although it can be present in more paralogs in other species.

What is the DICER1 gene? Everyone inherits two copies of the DICER1 gene from their parents, one from their mother and one from their father. This gene works to manage the function of other genes. In most people, this gene works properly.

2023年2月22日 · Human DICER (hDICER, also known as DICER1) is specialized for cleaving small hairpin structures such as precursor microRNAs (pre-miRNAs) and has limited activity towards long dsRNAs—unlike its...

The enzyme Dicer is best known for its role as a riboendonuclease in the small RNA pathway. In this canonical role, Dicer is a critical regulator of the biogenesis of microRNA and small interfering RNA, as well as a growing number of additional ...

Dicer is a general name for RNase III endoribonucleases producing small RNAs for RNA silencing pathways. There is a common order of specific modules present in Dicer across eukaryotic kingdoms, which reflects the common order of protein domains in the primary protein sequence.

2014年4月24日 · DICER1 tumor predisposition (DICER1) is characterized by an increased risk for pleuropulmonary blastoma (PPB), pulmonary cysts, thyroid gland neoplasia (multinodular goiter, adenomas, and/or thyroid cancer), ovarian tumors (Sertoli-Leydig cell tumor, gynandroblastoma, and sarcoma), and cystic nephroma.

2021年11月16日 · In this review, we will summarize the structural features of DICER, describe its canonical and non-canonical roles, and discuss the most common regulatory mechanisms having an impact on DICER abundance and function.

2021年11月16日 · In this review, we will summarize the structural features of DICER, describe its canonical and non-canonical roles, and discuss the most common regulatory mechanisms having an impact on DICER abundance and function.

2014年9月1日 · In the continuum of RNA interference (RNAi) phenomena, the highly conserved RNase III enzyme Dicer (DICER1 in Homo sapiens) lies at the crux of the biogenesis process for most small RNAs. Its...

Dicer is one of the key enzymes to process pre-miRNAs into mature miRNAs during miRNA biogenesis. In a retina-specific Dicer conditional knockout (ko) model, Chx10-cre, Dicerflox, Damiani et al. reported that levels of mature miRNAs were decreased in the ko retinas.