2016年10月1日 · Del(13q) involving the band q14, found in more than 50% of CLL patients, is the most common cytogenetic abnormality detected by FISH, and has been associated with good prognosis.

13q deletion syndrome is a rare genetic disease caused by the deletion of some or all of the large arm of human chromosome 13. Depending upon the size and location of the deletion on chromosome 13, the physical and mental manifestations will vary.

2024年11月5日 · Monoallelic deletion 13q (del(13q)) is the most common genomic aberration in chronic lymphocytic leukemia (CLL) and is associated with favorable prognosis when occurring as sole abnormality.

2017年12月7日 · INTRODUCTION: Chronic lymphocytic leukemia (CLL) with deletion 13q (del13q) has historically better outcome after chemotherapy. However a sizeable number of such patients do progress with a decreased progression free survival (PFS) and overall survival (OS).

2004年3月1日 · In a large survey of 325 patients with CLL by FISH, del(13q) was the commonest genetic aberration, detected in 55% of cases, and correlated with the longest survival of 92 months. The subcategory of isolated del(13q) was also associated with the longest median survival time of 133 months.

Expressed sequences as candidates for a novel tumor suppressor gene at band 13q14 in B-cell chronic lymphocytic leukemia and mantle cell lymphoma. 13q14 deletion in non-Hodgkin's lymphoma: correlation with clinicopathologic features. Cyclin D1 overexpression allows identification of an aggressive subset of leukemic lymphoproliferative disorder.

2012年11月16日 · 13q deletions (del (13q)) are the most frequent abnormalities in CLL and, if present as a sole abnormality, associated with favorable outcome. Since the size of the deletion varies considerably, class I (del (13q) not including the RB1 locus) and class II (del (13q) including the RB1 locus) deletions were defined.

2025年2月22日 · This review discusses the variations in del(13q) aberrations in CLL, including a minimally deleted region (MDR), the anatomic sizes of deleted 13q regions, affected alleles, the clone sizes of del(13q), and their dynamic changes during disease progression.

2021年1月6日 · Deletion of 13q14 [del(13q)] is the most common cytogenetic change (50%) in chronic lymphoblastic leukemia (CLL), and it is a good prognostic factor if it is detected as a sole aberration by FISH.

2017年9月27日 · ~Del(13q) is one of the most common chromosomal abnormalities in CLL. Patients presenting with del13 abnormality as a sole chromosomal aberration usually have indolent biology, presentation and a long median survival.