2024年12月24日 · CRYAB (Crystallin Alpha B) is a Protein Coding gene. Diseases associated with CRYAB include Cardiomyopathy, Dilated, 1Ii and Myopathy, Myofibrillar, 2. Among its related pathways are Cellular responses to stimuli and Cellular response to heat stress.

CRYAB is a member of the small heat shock protein family, first discovered in the lens of the eye, and involved in various diseases, such as eye and heart diseases and even cancers, for example, breast cancer, lung cancer, prostate cancer, and ovarian cancer.

2025年2月9日 · Title: CRYAB suppresses ferroptosis and promotes osteogenic differentiation of human bone marrow stem cells via binding and stabilizing FTH1.

2019年5月30日 · This article reviews the regulation of CRYAB in the apoptotic inflammatory signaling pathway and its role in cancers progression and as a key role in anti-cancer therapy targeting CRYAB in an effort to improve outcomes for patients with metastatic disease.

We identified CRYAB as a new potential therapeutic target and predictive biomarker for CRC and found that CRYAB can be used as a prognostic indicator of immune status. We also found that relatively high expression of CRYAB and the methylation of CRYAB in tumor tissues are both related to the infiltration of immune cells.

2012年3月1日 · Activation of the human alpha-B-crystallin (CRYAB) gene is another well-documented example in which HMGA1 has been demonstrated to play a crucial role in recruiting both BRG-1 and AP-1 to a positioned nucleosome on the gene's promoter that is remodeled during transcriptional initiation.

2023年1月12日 · Purpose: There is evidence that the Crystallin Alpha B (CRYAB) gene is involved in the regulation of the tumor microenvironment and influences tumor prognosis in some cancers. However, the role of CRYAB gene in prognosis and immunology in …

CRYAB suppresses ferroptosis and promotes osteogenic differentiation of human bone marrow stem cells via binding and stabilizing FTH1. TGFbeta1-Induced Fibrotic Responses of Conjunctival Fibroblasts through the Wnt/beta-Catenin/CRYAB Signaling Pathway.

This crystallin has antiapoptotic and neuroprotective functions. CRYAB is the major target of CD4+ T cell immunity to the myelin sheath from multiple sclerosis brain. Ousman et al. (2007) demonstrated that CRYAB is a potent negative regulator acting as a brake on several inflammatory pathways in both the immune system and central nervous system.

2024年2月4日 · Clinical resource with information about CRYAB, Cataract 16 multiple types, Dilated cardiomyopathy 1II, Fatal infantile hypertonic myofibrillar myopathy, Myofibrillar myopathy 2, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.