Cyclooxygenase-3 (COX-3) is an enzyme that is encoded by the PTGS1 (COX1) gene, but is not functional in humans. COX-3 is the third and most recently discovered cyclooxygenase …

2002年10月15日 · Here we describe a third distinct COX isozyme, COX-3, as well as two smaller COX-1-derived proteins (partial COX-1 or PCOX-1 proteins). COX-3 and one of the PCOX-1 …

COX-3 is a variant of COX-1 which has retained intron-1 during translation and which is found in human tissues in a polyadenylated form. Selective inhibition of COX-3 will discover potent and …

These results support the view that analgesia and hypothermia due to paracetamol are mediated by inhibition of a third COX isoenzyme (designated COX-3). In cultured mouse macrophages, …

Finally, identification of a new isozyme, COX-3, suggests that it is the target for acetaminophen. 9 COX-3 was discovered by Northern analysis of canine cerebral cortex RNA using a COX-1 …

COX-3 is a splice variant of COX-1. COX-1 and 2 differ in many respects [31,32]. COX-1 is expressed in most tissues constitutively. COX-2, on the other hand, is usually absent in most …

Could this PGI 2 actually be formed by the COX-3 that Chandrasekharan et al. (2) have found in the heart and aorta? Or could varied products from just two distinct genes provide a family of …

Two cyclooxygenase isozymes, COX-1 and -2, are known to cata-lyze the rate-limiting step of prostaglandin synthesis and are the targets of nonsteroidal antiinflammatory drugs. Here we …

A novel COX-1 splice variant termed COX-3, sensitive to acetaminophen, was recently discovered by Simmons et al., and is considered to play a key role in the biosynthesis of prostanoids …

2003年4月1日 · A novel COX-1 splice variant termed COX-3, sensitive to acetaminophen, was recently discovered by Simmons et al., and is considered to play a key role in the biosynthesis …