Charcot-Marie-Tooth disease type 1A (CMT1A) is a type of inherited neurological disorder that affects the peripheral nerves. People with this disease experience weakness and wasting …

CMT1A is commonly referred to as “demyelinating” CMT. CMT1A, like other forms of CMT1, is inherited in an autosomal dominant fashion. This means you can inherit the disease from …

CMT1A is the most common form of CMT, comprising around 66 percent of all patients with CMT1. The disorder is caused by a duplication of the PMP22 gene on Chromosome 17. …

2023年3月8日 · Charcot-Marie-Tooth disease is also called hereditary motor and sensory neuropathy. Charcot-Marie-Tooth disease results in smaller, weaker muscles. You may also …

1998年9月28日 · Charcot-Marie-Tooth (CMT) hereditary neuropathy refers to a group of disorders characterized by a chronic motor and sensory polyneuropathy, also known as hereditary motor …

2025年1月6日 · A subtype of CMT1 called CMT1A is the most common type of CMT. It happens when a gene that is important to making the myelin sheath is duplicated and too much of the …

CMT1A gene therapy is a rapidly emerging and promising field. We suggest that direct silencing of overexpressed PMP22 closer to physiological levels is the most promising and effective …

CMT1A is the single most common form of Charcot-Marie-Tooth disease. This sub-type of CMT is caused by the duplication of the Peripheral Myelin Protein 22 (PMP22) gene, which leads to …

A subtype of CMT1 called CMT1A (caused by a duplication or, less commonly, a point mutation in the PMP22 gene on chromosome 17) accounts for around 70% to 80% of CMT1 cases, …

Charcot-Marie-Tooth disease type 1 (CMT1) is a group of autosomal dominant demyelinating peripheral neuropathies characterized by distal weakness and atrophy, sensory loss, foot …