An inversion is a chromosome rearrangement in which a segment of a chromosome becomes inverted within its original position. An inversion occurs when a chromosome undergoes a two breaks within the chromosomal arm, and the segment between the two breaks inserts itself in the opposite direction in the same chromosome arm.

Inversion can be used to study the behaviour of chromosomes during meiosis, such as, chromosome pairing, cytological crossing over and formation of bridges and fragments and various configurations at different meiotic stages.

Chromosomal inversions were first discovered in Drosophila almost a century ago and they were the first type of genetic variants to be studied [1–3].

Inversions have played a key role in the evolution of sex chromosomes. In groups like mammals, the Y chromosome is entirely blocked from recombining with the X chromosome along almost its entire length.

2024年11月23日 · A chromosome inversion is the detachment, 180° rotation, and reinsertion of part of a chromosome; this may have no effect on the organism, but if the inversion occurs within a gene or moves a gene away from its regulatory elements it can have an adverse effect.

5 天之前 · An inversion in a chromosome occurs when a segment breaks off and reattaches within the same chromosome, but in reverse orientation. DNA may or may not be lost in the process.

In chromosomal inversion, a DNA segment of a chromosome is reversed end to end, which takes place when a single chromosome undergoes breakage and rearrangement within itself (Fig. 1 B). Two types of inversion exist, i.e., paracentric and pericentric.

Chromosome 9 is highly susceptible to structural rearrangements, specifically to pericentric inversions. Various investigators have posited that inv (9) with different breakpoints could be the cause of several abnormal conditions in individuals, whereas others have considered it …

2010年9月28日 · Inversions have played a key role in the evolution of sex chromosomes. In groups like mammals, the Y chromosome is entirely blocked from recombining with the X chromosome along almost its entire length.

2023年8月8日 · We studied 35 common inversions classified from genotypes of 33,018 adults with European ancestry. The inversions at 2p22.3, 16p11.2, and 17q21.31 reach genome-wide significance, followed by 8p23.1 and 6p21.33, in their association with …