CX3CL1 is produced as a long protein (with 373-amino acid in humans) with an extended mucin -like stalk and a chemokine domain on top. The mucin-like stalk permits it to bind to the surface of certain cells. However a soluble (90 kD) version of this chemokine has also been observed.

2024年12月24日 · CX3CL1 (C-X3-C Motif Chemokine Ligand 1) is a Protein Coding gene. Diseases associated with CX3CL1 include Pityriasis Rosea and Vasculitis. Among its related pathways are MIF Mediated Glucocorticoid Regulation and GPCR downstream signalling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and …

CX3CL1是通过与趋化因子受体CX3CR1的相互作用来发挥其粘附和迁移功能。 可溶性CX3XL1可强烈趋化T细胞和单核细胞，而细胞结合的趋化因子促进白细胞强有力粘附到活化的内皮细胞上。

The reported role of CX3CL1 as a key regulator of cytotoxic T cell-mediated immunity is supported by several studies that demonstrate CX3CL1 as an important TIL-recruiting chemokine and a positive prognostic factor in colorectal, breast, and lung cancer.

CX3C亚家族只有一个趋化因子CX3CL1，也称为不规则趋化因子（fractalkine）或神经元趋化因子（neurotactin），是唯一膜结合性趋化因子，主要作用于单核细胞和中性粒细胞。

CX3CL1/fractalkine, which is a dual functional chemokine, on osteoblasts works as an adhesion molecule toward osteoclast precursors. Osteoblasts constitutively express CX3CL1 at high levels and may also use soluble CX3CL1 to attract osteoclast precursors.

CX3CL1 is produced in neurons and is a unique chemokine that is initially translated as a transmembrane protein but can be proteolytically processed to generate a soluble chemokine. CX3CL1 has been shown to signal through its sole receptor CX3CR1, which is located on microglial cells within the central nervous system (CNS).

The CX3CL1-CX3CR1 axis promotes chemotaxis of CX3CR1+ cells towards soluble CX3CL1 as well as adhesion of CX3CR1+ cells to membrane-bound CX3CL1 (11, 12). CX3CR1 activation induces signaling events (13).

2024年12月11日 · CX3CL1（C-X3-C motif chemokine ligand 1）是位于人类16号染色体长臂21区（16q21）的一个基因，编码一种独特的趋化因子，具有双重功能，既可以作为一种可溶性趋化因子，也可以作为一种细胞表面黏附分子。

CX3CR1 is a 7-transmembrane receptor for CX3CL1 and mediates both its adhesive and migratory functions. In addition, it is shown that CX3CL1 and CX3CR1 are involved in the pathogenesis of various clinical disease states, such as atherosclerosis, glomerulonephritis, cardiac allograft rejection, and rheumatoid arthritis.