2019年9月13日 · Autophagic CS degradation is achieved by targeting CS components through LIR-mediated interaction of GABARAPs with PCM1. Thus, we find that autophagy promotes …

2016年10月1日 · We show that PCM1 is expressed around centrioles and ciliary basal bodies in patient GBM biopsies and derived cell lines and that its localization is dynamic throughout the …

2017年7月24日 · We show that the centriolar satellite protein PCM1 regulates the recruitment of GABARAP to the pericentriolar material. In addition to residing on the pericentriolar material, …

2014年8月31日 · Centriolar satellites (CS) are small, spherical granules with a diameter of approximately 70–100 nm that cluster in the vicinity of the centrosome (Fig. 1 a, b). They can …

2016年5月5日 · In an effort to study the role of centriolar satellites in the assembly of primary cilia, we used CRISPR/Cas9-mediated gene-editing in retinal pigment epithelial cells (RPE1) to …

2019年7月7日 · To address this, we performed mass spectrometry (MS)‐based proteome profiling of centriolar satellites obtained by affinity purification of their key constituent, PCM1, from …

2024年4月19日 · In this work, we show that the small molecule necrosulfonamide (NSA), a known inhibitor of the human effector of cell death by necroptosis MLKL, 28 induces the oxidation and …

2024年12月25日 · PCM1 (Pericentriolar Material 1) is a Protein Coding gene. Diseases associated with PCM1 include Differentiated Thyroid Carcinoma and Thyroid Cancer, …

2019年9月13日 · Autophagic CS degradation is achieved by targeting CS components through LIR-mediated interaction of GABARAPs with PCM1. Thus, we find that autophagy promotes …

We show that CS degradation is mediated through a direct interaction between GABARAPs and an LC3-interacting region (LIR) motif in the CS protein PCM1. Autophagy-deficient systems …