Charcot-Marie-Tooth disease type 1A (CMT1A) is a type of inherited neurological disorder that affects the peripheral nerves. People with this disease experience weakness and wasting (atrophy) of the muscles of the lower legs beginning in adolescence; later they can also have hand weakness and sensory loss.

Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common form of CMT, accounting for about half of people with CMT. Learn more here.

2023年3月8日 · Charcot-Marie-Tooth disease is also called hereditary motor and sensory neuropathy. Charcot-Marie-Tooth disease results in smaller, weaker muscles. You may also experience loss of sensation and muscle contractions, and difficulty walking.

CMT Type 1 (CMT1) is defined as an autosomal dominant demyelinating form of Charcot-Marie-Tooth disease. Learn more about CMT1 and subtypes.

2025年1月6日 · Charcot-Marie-Tooth disease (CMT) is a group of genetic conditions that affect the nerves connecting the brain and spinal cord to the rest of the body. CMT is the most common inherited neuropathy. Neuropathy describes a nerve condition that causes pain, swelling, or …

2024年6月22日 · CMT type 1A, the most common CMT neuropathy, is caused by a 1.5-Mb duplication of chromosome 17p11.2, resulting in trisomy of PMP22. Due to its large size, this region is susceptible to frequent genomic rearrangements.

The CMTA is a nonprofit organization aimed at improving the lives of those impacted by CMT. Learn more and donate to help us create a world without CMT.

CMT1A is the single most common form of Charcot-Marie-Tooth disease. This sub-type of CMT is caused by the duplication of the Peripheral Myelin Protein 22 (PMP22) gene, which leads to the demyelination of the peripheral nerves.

2025年2月17日 · Charcot-Marie-Tooth disease can be divided into many different subtypes, depending on the specific genetic mutation you are affected by, the moment the first symptoms appear and whether the myelin sheath or the axon is affected by the condition.Some of the more common subtypes are: 1 2 Charcot-Marie-Tooth disease type 1a develops due to problems …

Charcot-Marie-Tooth disease type 1A (CMT1A) is a type ofinherited neurological disorder that affects the peripheral nerves. Affected individuals experience weakness and wasting (atrophy) of the muscles of the lower legs beginning in adolescence; later they experience hand weakness and sensory loss.