Cyclin-dependent kinase 7 - Wikipedia
Cyclin-dependent kinase 7, or cell division protein kinase 7, is an enzyme that in humans is encoded by the CDK7 gene. [5] The protein encoded by this gene is a member of the cyclin …
CDK7 Gene - GeneCards | CDK7 Protein | CDK7 Antibody
2024年12月24日 · CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, …
Cdk7: a kinase at the core of transcription and in the crosshairs of ...
Cdk7, associated with the transcription initiation factor TFIIH, is both an effector CDK that phosphorylates Pol II and other targets within the transcriptional machinery, and a CDK …
Emerging roles of cyclin-dependent kinase 7 in health and diseases
2024年10月15日 · Cyclin-dependent kinase 7 (CDK7) is the catalytic subunit of CDK-activating kinase (CAK), which phosphorylates CDK1/2/4/6 and RNA polymerase II (Pol II) to promote …
Cyclin-dependent kinase 7 (CDK7) inhibitors as a novel ... - Nature
2024年2月14日 · Cyclin-dependent kinase (CDK) 7 is aberrantly overexpressed in many types of cancer and is an attractive target for cancer therapy due to its dual role in transcription and cell …
Structural basis of Cdk7 activation by dual T-loop phosphorylation …
2024年8月3日 · Cyclin-dependent kinase 7 (Cdk7) is a master regulator of cell cycle progression and gene expression, by virtue of its ability to phosphorylate the activation segment, or T loop, …
New research sheds light on CDK7's role in cancer cell proliferation
3 天之前 · The research shows that novel cancer drugs designed to inhibit CDK7 can, within minutes, shut down gene expression pathways that drive cell proliferation in dozens of …
Breakthrough Study Sheds Light on Cancer-Promoting Enzyme, …
3 天之前 · New research from the University of Colorado Boulder has unveiled critical insights into the role of CDK7, a cyclin-dependent kinase that functions as a master regulator of cell …
Cdk7 is essential for mitosis and for in vivo Cdk-activating kinase ...
In an attempt to resolve this issue, we cloned the Drosophila cdk7 homolog and created null and temperature-sensitive mutations. Here we demonstrate that cdk7 is necessary for CAK activity …
CDK7 in breast cancer: mechanisms of action and therapeutic …
2024年4月11日 · This review delineates the biological roles of CDK7 and explicates the molecular pathways through which CDK7 exacerbates the oncogenic progression of breast cancer.