Cell division protein kinase 6 (CDK6) is an enzyme encoded by the CDK6 gene. [5] [6] It is regulated by cyclins, more specifically by Cyclin D proteins and Cyclin-dependent kinase …

2024年12月24日 · CDK6 (Cyclin Dependent Kinase 6) is a Protein Coding gene. Diseases associated with CDK6 include Microcephaly 12, Primary, Autosomal Recessive and Primary …

2015年1月1日 · Our findings define CDK6 as an important regulator of stem cell activation and an essential component of a transcriptional complex that suppresses Egr1 in HSCs and LSCs. A …

2024年7月11日 · In this issue of Blood, Mayer et al 1 analyze hematopoietic stem cells (HSCs) isolated from mice with mutations in the cell-cycle kinase cyclin dependent-kinase 6 (CDK6) to …

2020年7月23日 · By integrating chromatin occupancy profiles of NUP98-fusion proteins with transcriptome profiling upon acute fusion protein inactivation in vivo, we defined the core set of …

2023年4月14日 · CDK4/6 inhibitors are a class of drugs that target particular enzymes, called CDK4 and CDK6. CDK stands for cyclin-dependent kinase, and it is an enzyme that is …

CDK4/6 inhibitors are a class of medicines used to treat certain types of metastatic breast cancer, which is cancer that has spread to other parts of the body.

研究表明，肿瘤细胞中，该通路失调频繁出现，导致细胞持续分裂，促进肿瘤生长。 当受到有丝分裂信号刺激时，细胞周期蛋白D (cyclin D)与CDK4或者CDK6发生相互作用。 被激活的cyclin …

Forms a cytoplasmic complex with Hsp90/HSP90AB1 and CDC37. FBXO7-binding promotes D-type cyclin binding. Interacts with Kaposi's sarcoma herpesvirus (KSHV) V-cyclin and …

2023年11月10日 · The roles of cyclin-dependent kinase 6 (CDK6) in various cancers, including small cell lung carcinoma (SCLC), remain unclear. Here, 111,54 multi-center samples were …