Cadherin-2 is a transmembrane protein expressed in multiple tissues and functions to mediate cell–cell adhesion. In cardiac muscle, Cadherin-2 is an integral component in adherens junctions residing at intercalated discs, which function to mechanically and electrically couple adjacent cardiomyocytes.

2024年12月24日 · CDH2 (Cadherin 2) is a Protein Coding gene. Diseases associated with CDH2 include Agenesis Of Corpus Callosum, Cardiac, Ocular, And Genital Syndrome and Attention Deficit-Hyperactivity Disorder 8. Among its related pathways are Cell junction organization and Blood-Brain Barrier: Anatomy.

CDH2 belongs to the classic cadherin family of Ca2+-dependent cell adhesion molecules with a meticulously described dual role in cell adhesion and β-catenin signaling. During CNS development, CDH2 is involved in a wide range of processes including ...

CDH2 mutation affecting N-cadherin function causes attention-deficit hyperactivity disorder in humans and mice. Specific N-cadherin-dependent pathways drive human breast cancer dormancy in bone marrow.

2015年9月30日 · Thus, Cdh2 contributes to the establishment and maintenance of FGF signaling-dependent self-renewal in mEpiSCs through stabilization of FGFR1.

2025年1月4日 · Title: The gene expression of CALD1, CDH2, and POSTN in fibroblast are related to idiopathic pulmonary fibrosis. N-cadherin dynamically regulates pediatric glioma cell migration in complex environments.

2017年3月8日 · CDH2 encodes cadherin 2 (also known as N-cadherin), a protein that plays a vital role in cell adhesion, making it a biologically plausible candidate gene in ARVC pathogenesis.