2024年12月24日 · CDC42 (Cell Division Cycle 42) is a Protein Coding gene. Diseases associated with CDC42 include Takenouchi-Kosaki Syndrome and Nocarh Syndrome. Among its related pathways are Regulation of actin dynamics for phagocytic cup formation and GPCR Pathway.

Cdc42 localizes to membranes via a post-translational C-terminal geranylgeranyl lipid modification; however, it can be found as a soluble complex association with RhoGDI (Rho GDP-dissociation inhibitor), another means of regulating Cdc42’s activation.

Cdc42 impairs the insulin secretion and promotes IR via suppressing the activity of PAK-1. Cdc42 can affect IR in adipose tissue by (a) interaction of CIP4 with TC10; (b) Gαq/11 participating in Cdc42 and PI3K to mediate insulin signalling to glucose transport.

2025年2月9日 · Cdc42 is a critical regulator of T cell actin dynamics, T cell receptor clustering, and cell cycle entry. Cdc42 activity in specific locations at specific times is most critical for its function in T cell activation.

Recent studies by conditional gene targeting of cdc42 in mice have revealed its tissue- and cell type-specific role and provide definitive information of the physiological signaling functions of Cdc42 in vivo.

Cdc42 is the master regulator of cell polarity and has been extensively studied in a range of fungi. CDC42 is essential for viability in P. marneffei and C. albicans, but not in U. maydis (Bassilana et al., 2003; Boyce et al., 2003; Mahlert et al., 2006; Michel et al., 2002; Ushinsky et al., 2002).

Consistent with the involvement of Cdc42 in EMT-mediated cell movement, overexpression of the Cdc42 GEF, ARHGEF9, is commonly observed in hepatocellular carcinoma samples and correlates with increased Cdc42 activation, reduced E …

2025年1月4日 · Clinical resource with information about CDC42, Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients., Macrothrombocytopenia-lymphedema-developmental delay-facial dysmorphism-camptodactyly syndrome, and available tests.

2 天之前 · The activity-dependent growth and retraction of dendritic spines and their associated synapses is a vital component of the neural circuit plasticity that occurs during learning (1–4).The Rho guanosine triphosphatases (GTPases) RhoA, Cdc42, and Rac1 are important regulators of the spine actin cytoskeleton, and their activation in dendritic spines is required for the …

2018年3月29日 · Cdc42 acts as a collection point for signal transduction and regulates multiple signaling pathways. Moreover, recent studies show that in most human cancers Cdc42 is abnormally expressed and promoting neoplastic growth and metastasis.