CD99 antigen (Cluster of differentiation 99), also known as MIC2 or single-chain type-1 glycoprotein, is a heavily O-glycosylated transmembrane protein that is encoded by the CD99 gene in humans. [3] [4] [5] The protein has a mass of 32 kD.

2024年12月24日 · CD99 (CD99 Molecule (Xg Blood Group)) is a Protein Coding gene. Diseases associated with CD99 include Extraosseous Ewing Sarcoma and Lymphoblastic Lymphoma . Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation .

CD99 acts through homophilic interactions and enables homo- or heterotypic cell aggregation. CD99 can mediate diverse cellular processes such as adhesion, transendothelial migration, differentiation, and cell death, thereby affecting immune …

2021年8月10日 · 肿瘤细胞也表达cd99，我们分析了它在肿瘤进展和癌细胞tem中的作用。 肿瘤细胞 CD99 是与 EC 粘附所必需的，但会抑制内皮屏障的侵袭和迁移活性。 此外，肿瘤细胞中 CD99 的缺失导致肌动蛋白细胞骨架重新分布，并增加 Rho GTPase CDC42 的活性，而 Rho GTPase CDC42 以其在 ...

Anti-CD99 antibodies have shown therapeutic effects on certain types of cancer, especially on Ewing sarcoma and T cell acute lymphoblastic leukemia (ALL). This review summarizes the recent progress of CD99 in cancer research and targeting therapies, especially in cancer immunotherapy, which may help researchers understand the crucial roles of ...

This article reviews the research progress of CD99 in hematological diseases, explores the role of CD99 in myeloid and lymphocytic leukemia, and the significance of CD99 as a therapeutic target for hematological malignancies.

cd99，也称为mic2，是一种在人类中由cd99基因编码的细胞表面糖蛋白，具有跨膜结构，包括信号肽、胞外区、跨膜区和胞质区。 CD99在多种生物学过程中发挥作用，包括细胞黏附、细胞迁移、细胞死亡、免疫过程以及与炎症、肿瘤和癌症相关的其他关键过程。

CD99 is a cell surface protein with unique features and only partly defined mechanisms of action. This molecule is involved in crucial biological processes, including cell adhesion, migration, death, differentiation and diapedesis, and it influences processes associated with …

2022年2月28日 · CD99于1979年首次被发现，是人类胸腺来源白血病抗原。CD99是一种高度O型糖基化的跨膜蛋白（细胞表面和细胞外的蛋白质是O型糖基化的，其中蛋白质中最丰富的O型糖基化类型是GalNAc通过a型糖苷连接附着在蛋白质链的丝氨酸（Ser）或苏氨酸（Thr）上。

CD99, a cell adhesion molecule, is involved in the cell adhesion, apoptosis and tumor cell migration, infiltration, and invasion, and plays an important role in the development and progression of tumor. CD99 is abnormally expression in some tumors, which has potential v...