Cluster of differentiation CD79A also known as B-cell antigen receptor complex-associated protein alpha chain and MB-1 membrane glycoprotein, is a protein that in humans is encoded by the CD79A gene. [5]

CD79 is composed of two distinct chains called CD79A and CD79B (also known as Igα and Igβ); these form a heterodimer on the surface of a B cell stabilized by disulfide bonding. [1] CD79a and CD79b are both members of the immunoglobulin superfamily.

2024年12月24日 · CD79A (CD79a Molecule) is a Protein Coding gene. Diseases associated with CD79A include Agammaglobulinemia 3, Autosomal Recessive and Agammaglobulinemia 3. Among its related pathways are Autodegradation of the E3 …

2022年11月15日 · Our study highlights that CD79A and CD79B are required for surface IgM expression in human B cells and illuminates the importance of the IgM expression level for signaling and fitness.

Igα (CD79a)/Igβ (CD79b) are essential components of BCR that are indispensable for its functionality, signal initiation, and signal transduction. CD79a/CD79b-mediated BCR signaling is required for the survival of normal as well as malignant B cells via a wide signaling network.

1995年8月15日 · In this report, we describe a new anti-CD79a monoclonal antibody, JCB117, which reacts with human B cells in paraffin embedded tissue sections, including decalcified bone marrow trephines.

2025年1月4日 · Title: Mechanism of CD79A and CD79B Support for IgM+ B Cell Fitness through B Cell Receptor Surface Expression. CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia.

Our study highlights that CD79A and CD79B are required for surface IgM expression in human B cells and illuminates the importance of IgM expression level for signaling and fitness. The development and function of B cells depend on signals from the B-cell receptor (BCR).

2025年2月8日 · CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia. Clinicopathological significance of CD79a expression in classic Hodgkin lymphoma. Aberrant CD79a and/or PAX5 expression can be found in Acute Myelogenous Leukemia cases with RUNX1 mutations even without the translocation t(8; 21).

2022年10月13日 · The B cell antigen receptor (BCR) is composed of a membrane-bound class M, D, G, E or A immunoglobulin for antigen recognition 1,2,3 and a disulfide-linked Igα (also known as CD79A) and Igβ ...