Integrin alpha 4 - Wikipedia
CD49d is an integrin alpha subunit. It makes up half of the α4β1 lymphocyte homing receptor. The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are …
CD49d promotes disease progression in chronic lymphocytic leukemia…
2020年4月9日 · CD49d is a remarkable prognostic biomarker of chronic lymphocytic leukemia (CLL). The cutoff value for the extensively validated 30% of positive CLL cells is able to …
CD49d Is the Strongest Flow Cytometry–Based Predictor of Overall ...
2014年2月10日 · In this analysis of approximately 3,000 patients, CD49d emerged as the strongest flow cytometry–based predictor of OS and TFS in CLL.
CD49d - an overview | ScienceDirect Topics
CD49d is a surface subunit of the integrin heterodimer that is involved in promoting survival of the CLL cells through microenvironment derived growth signals. CD49d can be used as a reliable …
CD49d promotes disease progression in chronic lymphocytic ... - PubMed
2020年4月9日 · CD49d is a remarkable prognostic biomarker of chronic lymphocytic leukemia (CLL). The cutoff value for the extensively validated 30% of positive CLL cells is able to …
CD49d expression is an independent predictor of overall survival …
CD49d (integrin alpha 4) plays a critical role in leucocyte trafficking, activation, and survival, and also facilitates interactions between leucocytes and stromal cells found in the marrow or …
CD49d Is a New Marker for Distinct Myeloid-Derived Suppressor …
2010年7月1日 · We found CD49d (VLA4), a member of the integrin α-chain family of proteins, to be exclusively expressed on CD11b + Gr-1 dull/int cells. CD49d is composed of a α4 (CD49d) …
CD49d expression identifies a biologically distinct subtype of …
CD49d can be an activation marker, but more generally, appears to define a distinct subset of CLL. Observations linking CD49d expression to cell activation include increased frequency of …
CD49d prevails over the novel recurrent mutations as independent ...
2016年4月25日 · CD49d, the alpha-chain of the integrin heterodimer α4β1, was identified among the strongest predictors of overall survival (OS) in chronic lymphocytic leukemia (CLL), along …
Relevance of CD49d protein expression as overall survival and ...
2008年1月15日 · CD49d, whose expression was strongly associated with that of CD38 (P < .001) and ZAP-70 (P < .001), or with IGHV mutations (P < .001), was independent prognosticator for …
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