Epithelial cell adhesion molecule (EpCAM, CD326) is a pleiotropic molecule that potentially offers therapeutic applications in cancer treatment. Initially described as a dominant surface antigen on human colon carcinoma, it is a transmembrane glycoprotein mediating …

2025年3月12日 · CD326, also known as EpCAM, is a transmembrane glycoprotein widely recognized for its role in cancer biology. Frequently overexpressed in carcinomas, it has been implicated in tumor progression, metastasis, and immune modulation.

2007年1月9日 · Although epithelial cell adhesion/activating molecule (EpCAM/CD326) is one of the first tumour-associated antigens identified, it has never received the same level of attention as other...

2012年2月1日 · Epithelial cell adhesion molecule (EpCAM, CD326) is a pleiotropic molecule that potentially offers therapeutic applications in cancer treatment. Initially described as a dominant surface antigen on human colon carcinoma, it is a transmembrane glycoprotein mediating epithelial-specific intercellular cell–adhesion.

Humans with biallelic inactivating mutations in Epithelial Cell Adhesion Molecule (EpCAM) develop congenital tufting enteropathy (CTE). To gain mechanistic insights regarding EpCAM function in this disorder, we prepared intestinal epithelial cell (IEC) organoids and spheroids.

The epithelial cell adhesion molecule (EpCAM, CD326) is a glycoprotein of ∼40 kd that was originally identified as a marker for carcinoma, attributable to its high expression on rapidly proliferating tumors of epithelial origin.

2024年12月25日 · EPCAM (Epithelial Cell Adhesion Molecule) is a Protein Coding gene. Diseases associated with EPCAM include Diarrhea 5, With Tufting Enteropathy, Congenital and Lynch Syndrome 8. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Cytoskeletal Signaling.

2007年2月12日 · Although epithelial cell adhesion/activating molecule (EpCAM/CD326) is one of the first tumour-associated antigens identified, it has never received the same level of attention as other target proteins for therapy of cancer.

LC express high levels of epithelial cell adhesion molecule (EpCAM; CD326), a cell-surface protein that is characteristic of some epithelia and many carcinomas and that has been implicated in intercellular adhesion and metastasis.

CD326 also known as EpCAM (Epithelial Cell Adhesion Molecule) is a 40 kDa type I transmembrane glycoprotein expressed at the cell surface of a variety of epithelial cells. CD326 is a hemophilic Ca 2+ ‑independent cell-cell adhesion molecule which plays a major role in intercellular adhesion.