CD32 is expressed on all cells of the immune system, with the exception of T and NK cells, and it is the only classical Fc receptor on B cells where it regulates activating signals delivered by immune complexes to the B cell receptor (Nimmerjahn and Ravetch, 2006).

What is CD32? CD32, also known as Fc gamma receptor II (FcγRII), is a protein expressed on the surface of immune cells, including B cells, monocytes, and dendritic cells. It plays a key role in modulating immune responses by binding to the Fc region of immunoglobulin G (IgG). CD32 and Viral Infections HIV Latency and Persistence:

2019年3月19日 · The human FcγRII family (also known as CD32 in the Cluster of Differentiation nomenclature) consists of a family of primarily cell membrane receptor proteins. They are encoded by the mRNA splice variants of three highly related genes— FCGR2A, FCGR2B , and FCGR2C , which arose by recombination of the FCGR2A and FCGR2B genes ( 3 ).

2018年7月16日 · Our results demonstrate that CD32 expression is a marker of CD4+ T cell activation in HIV+ individuals and raises questions regarding the immune resting status of CD32+ cells harboring HIV-1 ...

CD32 is a critical regulator of immune responses, with significant implications for disease pathogenesis and treatment. From autoimmune diseases to cancer and infectious diseases, understanding the role of CD32 provides valuable insights into the immune system’s complexity and opens the door to novel therapeutic strategies.

CD32, a receptor belonging to the family of Fc gamma receptors (FcγRs), plays a pivotal role in modulating immune responses. While its involvement in normal immune regulation is well understood, recent research highlights its significant role in …

Analysis of CD32 expression in permeabilized cells revealed an increased proportion of CD4+CD32+ T cells (~9%), indicating that CD4+ T cells store a CD32 cytoplasmic pool. Activation of CD4+ T cells markedly increased the expression of CD32 …

CD32, CD32A, CDw32, FCG2, FCGR2, FCGR2A1, FcGR, FcgammaRIIa, IGFR2 Chromosome: 1; Location: 1q23.3. Tests; Conditions; OMIM; More about this gene; 2. FCGR2B - Fc gamma receptor IIb. The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis ...

Despite reduced surface expression of CD32, B cells from donors with RA are susceptible to inhibition through CD32b. (A) CD19 (upper panel) or CD32 (lower panel) surface expression was measured on blood B cells from HCs and patients with RA.

2023年2月15日 · CD32 is a protein expressed on various cell types, including B cells, T cells, monocytes, dendritic cells, and epithelial cells, among others. It plays a role in immune responses and is not expressed on fully differentiated plasma B cells.