CD28 signals play a key role in many T cell processes including cytoskeletal remodeling, production of cytokines, survival, and differentiation. CD28 ligation leads to unique epigenetic, transcriptional, and post-translational changes in T cells that cannot be …

2024年12月24日 · CD28 (CD28 Molecule) is a Protein Coding gene. Diseases associated with CD28 include Immunodeficiency 123 With Hpv-Related Verrucosis and Classic Mycosis Fungoides. Among its related pathways are CD28 co-stimulation and Constitutive Signaling by Aberrant PI3K in Cancer.

CD28 is a disulfide-linked homodimer constitutively expressed on the surface of T cells. Virtually all murine T cells express CD28, whereas in human T cells, nearly all CD4 + and 50% of CD8 + cells express CD28. The CD28 − subset of T cells appears to represent a population that has undergone chronic activation and can manifest suppressive ...

CD28 is a homodimeric stimulatory cell surface receptor of the Ig superfamily. It is expressed on virtually all T-cells in rodents, and on the vast majority of CD4 + but only about half of circulating human CD8 + T-cells. The control of T-cell responses by CD28 co-stimulation provides a means of preventing unwanted (anti-self) and triggering ...

In this paper, we mainly introduce the structure of CD28 and its related biological functions, as well as the application of costimulatory pathways targeting CD28 in disease treatment.

The major roles of CD28 co-stimulation. CD28 stimulation modulates proliferation, differentiation and effecter functions in T cells by regulation of gene transcription, cell cycle progression, survival, secretion of cytokines and chemokines, metabolism and …

2024年7月25日 · We describe how CD28 is central to the success of current cancer immunotherapies and examine how new questions arising from studies of CD28 as a clinical target have enhanced our understanding...

2001年12月1日 · Recent studies have reconstituted expression of mutant CD28 molecules in T cells either by transgenic expression of Y170F constructs into CD28-deficient mice, or by retroviral transduction...

2003年12月1日 · In this review, we discuss recent genetic, biochemical and biophysical data that indicate a modified view of the molecular mechanism by which ligation of CD28 amplifies TCR-mediated T-cell...

2024年11月5日 · CD28 is a positive costimulatory signaling molecule expressed constitutively by T-cells that binds to CD80 and CD86 on antigen-presenting cells; CD28 receptor engagement initiates 'Signal 2' pathways important for T-cell activation, …