CD1 (cluster of differentiation 1) is a family of glycoproteins expressed on the surface of various human antigen-presenting cells.

This Review describes the journey taken by the MHC-class-I-like CD1 molecules, detailing their assembly, intracellular trafficking and loading with lipid antigens.

The CD1 proteins are a family of non-polymorphic, MHC class I-related molecules that present lipid antigens to subsets of T lymphocytes with innate- or adaptive-like immune functions. Recent studies have provided new insight into the identity of ...

This review summarizes the major features of CD1 genes and proteins, the patterns of intracellular trafficking of CD1 molecules, and how they sample different intracellular compartments for self- and foreign lipids.

2021年5月13日 · CD1e is an intermediate form, expressed intracellularly (J Biol Chem 2000;275:37757) Pathophysiology: Cellular infection with Mycobacteria tuberculosis or exposure to mycobacterial cell wall products converts CD1- myeloid precursors into competent CD1+ antigen presenting cells (J Immunol 2005;175:1758)

CD1 molecules are well known for their role in binding and presenting lipid antigens to mediate the activation of CD1-restricted T cells.

2016年9月9日 · Group 2 CD1 proteins (CD1d) present diverse endogenous and exogenous lipid antigens to subsets of natural killer T (NKT) cells expressing semi-invariant, biased, or diverse TCRs. α-Linked glycosylceramides have emerged as major endogenous ligands that control the functions of invariant NKT cells.

Here, we summarize the molecular properties of the CD1 isoforms, their lipid antigens, and CD1-restricted T cells, with particular focus on CD1a. We then discuss the roles that CD1a-reactive T cells play in several diseases.

The CD1 molecules bind and present amphipathic lipid antigens for recognition by T-cell receptors. Here, we outline the recent advances in our understanding of how the processes of CD1 assembly, trafficking, lipid-antigen binding and T-cell activation are achieved and the new insights into how lipid antigens differentially elicit CD1-restricted ...

CD1 molecules are glycosylated heterodimers composed of a heavy chain polypeptide non-covalently associated with β2-microglobulin (β2m). Group I and II CD1 proteins are mainly expressed on cortical thymocytes, B-cell (CD1c), and antigen presenting cells (APC), such as dendritic cells (DC).