B-lymphocyte antigen CD19, also known as CD19 molecule (Cluster of Differentiation 19), B-Lymphocyte Surface Antigen B4, T-Cell Surface Antigen Leu-12 and CVID3 is a transmembrane protein that in humans is encoded by the gene CD19.

The CD19 antigen (aka B-lymphocyte antigen CD19 or Cluster of Differentiation 19) plays an important role in clinical oncology. It’s a protein found on the surface of B-cells , a type of white blood cell.

2024年12月24日 · CD19 (CD19 Molecule) is a Protein Coding gene. Diseases associated with CD19 include Immunodeficiency, Common Variable, 3 and Common Variable Immunodeficiency. Among its related pathways are Constitutive Signaling by Aberrant PI3K in Cancer and PIP3 activates AKT signaling.

2012年11月29日 · CD19 is a biomarker for normal and neoplastic B cells, as well as follicular dendritic cells. CD19 is critically involved in establishing intrinsic B cell signaling thresholds through modulating both B cell receptor-dependent and independent signaling.

CD19 serves as a pivotal component in the understanding of B-cell biology, making its study fundamental in hematological diagnostics. This introduction outlines the significance of CD19, a protein found on the surface of B-lymphocytes, which are essential for the immune response.

CD19 is a critical marker and functional component of B-cells, playing a significant role in the immune response. Its presence on B-cells is leveraged in both diagnostic and therapeutic contexts to manage and treat various immune-related conditions and cancers.

2003年12月1日 · CD19 promotes the proliferation and survival of mature B cells, but its role in early B cell development is less well understood. Here we identify and characterize impairments in early B cell development in CD19 −/− mice.

2017年1月5日 · In their article, Braig et al describe 4 patients with B-cell ALL (B-ALL) who developed CD19 – relapse. All of them maintained a purely B-ALL phenotype, ruling out myeloid switch. For 1 patient, they performed a detailed analysis to …

CD19+ B cells are a type of white blood cell that plays a fundamental role in the immune system's ability to respond to infections and produce antibodies. When the percentage of CD19+ B cells is lower than normal, it can suggest several underlying factors or conditions, including:

CD19 is primarily a transmembrane glycoprotein that functions as a co-receptor in B-cell signaling pathways, effectively magnifying signals from the B-cell receptor. It is composed of a variable extracellular domain, a single transmembrane segment, and a short cytoplasmic tail.