C-C chemokine receptor type 2 (CCR2 or CD192 (cluster of differentiation 192) is a protein that in humans is encoded by the CCR2 gene. [5] CCR2 is a CC chemokine receptor.

2024年12月24日 · CCR2 (C-C Motif Chemokine Receptor 2) is a Protein Coding gene. Diseases associated with CCR2 include Polycystic Lung Disease and Human Immunodeficiency Virus Type 1. Among its related pathways are Class A/1 (Rhodopsin …

By interacting with CCR2, CCL2 promotes cancer cell migration and recruits immunosuppressive cells to the tumour microenvironment, favouring cancer development. Over the last several decades, a series of studies have been conducted to explore the CCL2-CCR2 signalling axis function in malignancies.

收集野生型c57bl/6和纯合b-hccr2小鼠的骨髓，并用种属特异性抗ccr2抗体进行流式细胞术分析。 结果显示：鼠CCR2仅在野生小鼠中检测到，人CCR2仅在纯合B-hCCR2小鼠中检测到。

2025年1月13日 · ccr2是cc2型化疗素受体，也称为单核细胞吸引蛋白1受体（mcp-1-r）或cd192。 CCR2是CCL2的关键功能受体。 CCR2/CCR2轴直接促进了许多类型的具有CCR2的肿瘤的存活/生长和浸润/转移。

关于 ccr2 Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:46,354,111-46,360,940 (from NCBI) This gene has 4 transcripts (splice variants), 151 orthologues and 23 paralogues.

2023年3月13日 · CCR2蛋白（Chemokine (C-C motif) receptor 2）是一种存在于免疫细胞表面上的膜蛋白，包括单核细胞、巨噬细胞和T细胞等。 CCR2蛋白是一种趋化因子受体，它可以与特定的趋化因子结合，如单核细胞趋化蛋白1（MCP-1），从而在炎症和免疫反应中发挥重要作用。

ccr2信号似乎通过破坏 树突状细胞 的成熟来实现免疫抑制，树突状细胞是最重要的抗原呈递细胞，对免疫应答的启动至关重要。与表达ccr2的癌细胞相比，由不表达ccr2的细胞所产生的肿瘤中，成熟树突状细胞和活化的 cd8+杀伤t细胞 的浸润性更高。

2023年1月31日 · C-C chemokine receptor 2 (CCR2) is a dual-function receptor. Similar to other G protein–coupled chemokine receptors, it promotes monocyte infiltration into tissues in response to the chemokine CCL2...

2023年9月1日 · C–C motif chemokine receptor 2 (CCR2), together with its ligands, especially C–C motif ligand 2 (CCL2), to which CCR2 has the highest affinity, form a noteworthy signaling pathway in recruiting macrophages for the immune responses among variegated disorders in …