2024年12月24日 · C1QB (Complement C1q B Chain) is a Protein Coding gene. Diseases associated with C1QB include C1q Deficiency 2 and C1q Deficiency 1. Among its related pathways are Complement cascade and Initial triggering of complement. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity.

C1q is a 460 kDa protein formed from 18 peptide chains in 3 subunits of 6. Each 6 peptide subunit consists of a Y-shaped pair of triple peptide helices joined at the stem and ending in a globular non-helical head.

Official gene symbol, which is typically a short form of the gene name, according to HGNC. Assigned HPA protein class (es) for the encoded protein (s). Number of protein-coding transcripts from the gene as defined by Ensembl.

2023年4月12日 · HGNC Approved Gene Symbol: C1QB. Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38) : 1:22,653,236-22,661,637 (from NCBI) C1q, the first subcomponent of C1, has a complicated 18-chain structure: 6 A, 6 B, and 6 C chains.

It can be caused by genetic changes in the C1QA, C1QB or C1QC genes and is inherited in an autosomal recessive pattern. C1q deficiency is a rare disorder associated with recurrent skin lesions, chronic infections, systemic lupus erythematosus (SLE) or SLE-like diseases.

MafB directly regulates all C1q genes, including the promoter regions of C1qa, C1qb, and C1qc. However, the regulation of C1q production at the molecular level is still incompletely understood....

2024年11月5日 · C1qbp is a crucial element of cell adhesion and metastasis, 2 and this link between tumor and macrophage can severely limit effective therapy: BMDM following stimulation/polarization with MM lines, but not naïve/unstimulated BMDM, strongly inhibit anti-BCMA CAR T in vitro cytotoxic activity.

2021年5月18日 · 该文献中主要是定义了一个新的DC细胞亚群，并探讨了其功能。 M-c1-THBS1 ：与MDSC（myeloid-derived suppressor cell）细胞相似的基因表达；S100A, FCN1,VCAN,低表达HLA-related genes;转录因子：BCL3，NR4A1，RXRA，TCF25. 该文献对于髓系细胞的注释非常全面。 主要根据文献中的描述与方法 髓系细胞分类 巨噬细胞，单核细胞，DC细胞 文献 …

2024年12月24日 · C1QBP (Complement C1q Binding Protein) is a Protein Coding gene. Diseases associated with C1QBP include Combined Oxidative Phosphorylation Deficiency 33 and Chanarin-Dorfman Syndrome. Among its related pathways are Signaling by Rho GTPases and Intrinsic Pathway for Apoptosis.

This gene encodes the B-chain polypeptide of serum complement subcomponent C1q, which associates with C1r and C1s to yield the first component of the serum complement system. C1q is composed of 18 polypeptide chains which include 6 A-chains, 6 B-chains, and 6 C-chains.