2023年4月3日 · Bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl (BPTES), a potent orally available GLS1 inhibitor that spares GLS2, shows promising antitumor effects against human...

2016年9月6日 · In this study, we used a proprietary emulsification process to encapsulate bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES), a selective but relatively …

BPTES (10 μM) reduces glutaminase activity in both WT and mutant IDH1 expressing cells, diminishes glutamate and α-KG levels, and increases glycolytic intermediates while leaving …

2020年10月25日 · Unlike the glutamine mimetics, the allosteric inhibitors such as BPTES and CB-839, are selectively targeting glutaminase without disturbing other aspects of glutamine …

BPTES prolongs survival of a genetically engineered mouse model of liver cancer. Based on the observation that loss of 1 copy of Gls could delay tumorigenesis, we sought to determine …

2023年7月5日 · Bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide (BPTES) is a selective inhibitor of glutaminase-1 (GLS1), consequently inhibiting glutaminolysis. BPTES is …

In this study, we used a proprietary emulsification process to encapsulate bis-2- (5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES), a selective but relatively …

BPTES is a selective inhibitor of Glutaminase GLS1. Vaccinia virus (VACV) requires glutamine metabolism for its optimal replication. Inhibition of glutaminolysis by bis-2-(5-phenylacetamido …

BPTES diminished the viability and migration of PCa cells, while increasing caspase-3 activity. CRPC cells were found to be more dependent on glutamine and more sensitive to glutaminase …