A BRAF mutation is a spontaneous change in the BRAF gene that makes it work incorrectly. A mutation causes the gene to turn on the protein and keep it on, which means certain cells get ongoing signals to keep dividing and no instructions on when to stop.

BRAF is a human gene that encodes a protein called B-Raf. The gene is also referred to as proto-oncogene B-Raf and v-Raf murine sarcoma viral oncogene homolog B, while the protein is more formally known as serine/threonine-protein kinase B-Raf. [5] [6]

2024年6月23日 · BRAF mutations are DNA changes in some cancer cells that can be treated with newer targeted therapies. BRAF mutations are found in roughly half of melanomas. Medications that target these mutations have significantly improved the survival rates of metastatic melanoma.

2025年1月22日 · BRAF is one type of lung cancer biomarker. BRAF is the name of both a gene and a protein. The BRAF protein helps control cell growth. When there is a mutation in the BRAF gene, it creates an abnormal protein that sends signals that lead to …

2024年4月16日 · In this review, we cover the current understanding of BRAF mutations and associated clinical characteristics in patients with metastatic NSCLC, approved and emerging treatment options, BRAF...

2025年1月22日 · BRAF Mutation Analysis Assay is based on PCR amplification and detection of target DNA using complementary primer pairs and oligonucleotide probes labeled with fluorsescent dyes. This assay is designed to detect V600 mutations E, K, D, R, and G. For solid tumors, tumor enrichment is performed before extraction.

2024年12月24日 · BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase) is a Protein Coding gene. Diseases associated with BRAF include Lung Cancer and Cardiofaciocutaneous Syndrome 1. Among its related pathways are IL-9 Signaling Pathways and Prolactin Signaling.

The BRAF gene encodes for a serine/threonine protein kinase that participates in the MAPK/ERK signalling pathway and plays a vital role in cancers and developmental syndromes (RASopathies).

2025年2月8日 · functional analysis of human BRaf disease-linked mutations identified BRaf as the key missing signaling effector in the common synaptic NMDA-R-CaMKII-SynGap-Ras-BRaf-MEK-ERK transduction cascade. BRAF mutation is not associated with pheochromocytoma.

A) BRAF mutants are classified based on their dependence on upstream RTK/RAS activation and dimerization for kinase activation.B) Schematic showing BRAF V600E inhibition by αC-helix IN/DFG OUT RAF inhibitors (left) as compared to paradoxical activation of RAF dimers (right). For BRAF, residue R509 located at the C-terminal portion of the αC-helix is fundamental for dimer …