2022年8月3日 · Anti-ASGR1 neutralizing antibody lowers lipid levels by increasing cholesterol excretion, and shows synergistic beneficial effects with atorvastatin or ezetimibe, two widely used...

2024年12月24日 · ASGR1 (Asialoglycoprotein Receptor 1) is a Protein Coding gene. Diseases associated with ASGR1 include Hepatitis and Hepatitis B. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification.

2023年1月23日 · ASGR1 is a receptor localized on the surface of hepatocytes, which renders it possible to perform structure-based drug discovery to identify ligand analogs or small-molecule compounds that can ...

2024年3月8日 · Here we show that asialoglycoprotein receptor 1 (ASGR1), a lectin specifically expressed in the liver, is downregulated in patients with liver fibrosis or cirrhosis and male mice with liver...

2021年4月8日 · The hepatic carbohydrate-recognizing asialoglycoprotein receptor (ASGR1) mediates the endocytosis/lysosomal degradation of desialylated glycoproteins following binding to terminal galactose/N-acetylgalactosamine.

The receptor comprises two proteins, asialoglycoprotein receptor 1 and 2 (ASGR1 and ASGR2), encoded by the genes ASGR1 and ASGR2. Design and Methods . Using reverse transcription amplification (RT-PCR), expression of ASGR1 and ASGR2 was investigated in human peripheral blood monocytes.

Background. The asialoglycoprotein receptor (ASGPR) is a hepatic receptor that mediates removal of potentially hazardous glycoconjugates from blood in health and disease. The receptor comprises two proteins, asialoglycoprotein receptor 1 and 2 (ASGR1 and ASGR2), encoded by the genes ASGR1 and ASGR2. …

2024年11月30日 · In this study, we investigated the impact of ASGR1 deficiency (ASGR1 −/−) on atherosclerosis by evaluating its effects on plaque formation, lipid metabolism, circulating immunoinflammatory response, and circulating N -glycome under the hypercholesterolemic condition in ApoE-deficient mice.

2023年7月3日 · Asialoglycoprotein receptor 1 (ASGR1) is emerging as a potential drug target to reduce low-density lipoprotein (LDL)-cholesterol and coronary artery disease (CAD) risk. Here, we investigated genetically mimicked ASGR1 inhibitors on all-cause mortality and any possible adverse effects.

2024年10月31日 · The asialoglycoprotein receptor is a hepatocyte-specific lectin-type receptor, and ASGR1 is its main subunit. 4 ASGR1 binds to circulating glycoproteins and removes them from circulation by endocytosis and lysosomal degradation.