Argonaute proteins associate with small non-coding RNAs (such as small interfering (si)RNAs and microRNAs (miRNAs)) and function in RNA-based silencing mechanisms by altering protein synthesis...

2013年6月4日 · Argonaute proteins are highly specialized binding modules that accommodate the small RNA component — such as microRNAs (miRNAs), short interfering RNAs (siRNAs) or PIWI-associated RNAs (piRNAs) —...

2020年7月1日 · Argonaute proteins play an important role in post-translational gene silencing and the biogenesis of small RNA. Accumulating studies have revealed that Argonaute proteins also implicate several other cellular processes, such as host …

2011年6月21日 · What are Argonaute proteins? Argonaute proteins form an evolutionarily conserved family whose members silence gene expression in pathways such as RNA interference (RNAi). Argonaute family proteins can be divided into AGO and PIWI proteins (Figure 1).

Here, we review the roles of Argonaute proteins during early development by focusing on the interplay between specific domains of the protein and their function. Moreover, we report recent works highlighting the importance of AGO posttranslational modifications in cancer.

2020年1月21日 · Here, we review the roles of Argonaute proteins during early development by focusing on the interplay between specific domains of the protein and their function. Moreover, we report recent works highlighting the importance of AGO posttranslational modifications in cancer.

2000年5月24日 · What is an Argonaut? The word “argonaut” (Ancient Greek: Ἀργοναῦται) comes from an ancient tale sung of the strongest and bravest band of heroes ever assembled in Greek Mythology — Jason and the Argonauts — and literally means “sailors of the Argo.” This myth chronicles Jason’s quest for the Golden Fleece and the restoration of his family’s throne.

2025年1月15日 · Argonaute (Ago) proteins use small nucleic acid guides to identify and regulate complementary DNA or RNA target sequences.

2020年4月29日 · Argonaute proteins are highly conserved in almost all organisms. They not only involve in the biogenesis of small regulatory RNAs, but also regulate gene expression and defend against foreign pathogen invasion via small RNA-mediated gene silencing pathways.

2008年9月2日 · Argonaute proteins were first discovered genetically, and extensive research in the past few years has revealed that members of the Argonaute protein family are key players in gene-silencing pathways guided by small RNAs.