Multidrug resistance-associated protein 5 is a protein that in humans is encoded by the ABCC5 gene. [5][6][7] The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes.

2024年12月24日 · ABCC5 (ATP Binding Cassette Subfamily C Member 5) is a Protein Coding gene. Diseases associated with ABCC5 include Currarino Syndrome and Primary Angle-Closure Glaucoma. Among its related pathways are Glycosaminoglycan metabolism and Blood-Brain Barrier and Immune Cell Transmigration: Overview.

2025年2月8日 · ABCC5 transporter is a novel type 2 diabetes susceptibility gene in European and African American populations. ABCC5 functions as a mediator of breast cancer skeletal metastasis. ABCC5 expression in breast cancer cells is important for efficient osteoclast-mediated bone resorption.

The expression of ABCC5 was dramatically induced in sorafenib-resistant HCC cells and was remarkably associated with poor clinical prognoses. The down-regulation of ABCC5 expression could significantly reduce the resistance of sorafenib to HCC cells.

2024年6月17日 · ABCC5 facilitates the acquired resistance of sorafenib through the inhibition of SLC7A11-induced ferroptosis in hepatocellular carcinoma. Pan-cancer analysis and single-cell analysis revealed the role of ABCC5 transporter in hepatocellular carcinoma. Inhibition of ABCC5-mediated cGMP transport by progesterone, testosterone and their analogues.

2015年12月18日 · The ubiquitous efflux transporter ABCC5 (ATP-binding cassette subfamily C member 5) is present at high levels in the blood-brain barrier, neurons, and glia, but its in vivo substrates and function are not known.

2024年11月5日 · As a member of the family of ABC transporter proteins, ABCC5 (ATP Binding Cassette Subfamily C Member 5) reduces the intracellular concentration of a drug and its subsequent effectiveness using an ATP-dependent method to pump the drug out of the cell.

2024年11月4日 · ABCC5 mediates drug resistance and promotes tumour proliferation and metastasis in different types of cancer (Chen et al., 2022; Chen et al., 2021a). Fewer studies have been conducted on ABCC5, and there is minimal literature detailing the role of ABCC5 in cancer drug resistance.

2014年3月6日 · We found that a genetic variant within ABCC5 was associated with an increased risk of having PACG. Our findings suggest that the increase in PACG risk could in part be mediated by genetic sequence variants that influence the anterior chamber dimensions of the eye.

Description: Homo sapiens ATP binding cassette subfamily C member 5 (ABCC5), transcript variant 1, mRNA. (from RefSeq NM_005688) RefSeq Summary (NM_005688): The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes.